Puga Fernanda, Veiga Heloisa, Cagy Mauricio, McDowell Kaleb, Piedade Roberto, Ribeiro Pedro
Laboratório de Mapeamento Cerebral e Integração Sensório-Motora, Instituto de Psiquiatria (IPUB), Universidade Federal do Rio de Janeiro, Rio de Janeiro RJ, Brazil.
Arq Neuropsiquiatr. 2005 Jun;63(2A):228-34. doi: 10.1590/s0004-282x2005000200008.
Benzodiazepines have been used in the pharmacological treatment of anxiety for over four decades. However, very few studies have combined bromazepam and event-related potentials (ERP). The present study aimed at investigating the modulatory effects of this drug on brain dynamics. Specifically, the effects of bromazepam (3 mg) on the P300 component of the ERP were tested in a double-blind experiment. The sample, consisting of 15 healthy subjects (7 male and 8 female), was submitted to a visual discrimination task, which employed the "oddball" paradigm. Electrophysiological (P300) and behavioral measures (stroop, digit span, and reaction time) were analyzed across three experimental conditions: placebo 1, placebo 2, and bromazepam. Results suggest that the effects of bromazepam (3 mg) on cognitive processes are not apparent. In spite of what seems irrefutable in current literature, bromazepam did not produce evident effects on the behavioral and electrophysiological variables analyzed.
四十多年来，苯二氮䓬类药物一直用于焦虑症的药物治疗。然而，将溴替唑仑与事件相关电位（ERP）相结合的研究非常少。本研究旨在探讨该药物对脑动力学的调节作用。具体而言，在一项双盲实验中测试了溴替唑仑（3毫克）对ERP的P300成分的影响。该样本由15名健康受试者（7名男性和8名女性）组成，他们接受了一项采用“oddball”范式的视觉辨别任务。在三个实验条件下分析了电生理（P300）和行为指标（斯特鲁普、数字广度和反应时间）：安慰剂1、安慰剂2和溴替唑仑。结果表明，溴替唑仑（3毫克）对认知过程的影响并不明显。尽管当前文献中的观点似乎无可辩驳，但溴替唑仑对所分析的行为和电生理变量并未产生明显影响。
