Jansen A A, Verbaten M N, Slangen J L
State University Utrecht, NIDDR, Faculty of Pharmacy, The Netherlands.
Neuropsychobiology. 1988;20(2):91-5. doi: 10.1159/000118481.
Effects of 6 and 12 mg bromazepam on reaction time, stimulus sensitivity and response bias in a 1-hour visual attention task, on smooth pursuit eye movements, and on performance in the digit symbol substitution test (DSST) were investigated in 12 healthy male volunteers. It was a placebo-controlled, double-blind, crossover study that used repeated measures. Three saliva samples and a blood sample were taken for correlating drug concentration and performance. Bromazepam lowered stimulus sensitivity dose-dependently. Response times for hits and response bias were affected by the 12-mg dose only. DSST performance decreased dose-dependently. Smooth pursuit was equally impaired by 6 and 12 mg. Concentrations in serum correlated with concentrations in saliva, but serum and saliva concentrations did not correlate with task performance.
在12名健康男性志愿者中，研究了6毫克和12毫克溴西泮对1小时视觉注意力任务中的反应时间、刺激敏感性和反应偏差、平稳跟踪眼球运动以及数字符号替换测试（DSST）表现的影响。这是一项采用重复测量的安慰剂对照、双盲、交叉研究。采集了三份唾液样本和一份血液样本，以关联药物浓度和表现。溴西泮剂量依赖性地降低刺激敏感性。只有12毫克剂量影响了命中反应时间和反应偏差。DSST表现剂量依赖性地下降。6毫克和12毫克剂量对平稳跟踪的损害程度相同。血清浓度与唾液浓度相关，但血清和唾液浓度与任务表现无关。
