Mousa Shaker A
The Pharmaceutical Research Institute, Albany College of Pharmacy, 106 New Scotland Avenue, Albany, NY, USA.
Mol Biotechnol. 2008 Jan;38(1):33-40. doi: 10.1007/s12033-007-0072-7. Epub 2007 Aug 15.
The role of cell adhesion molecules (CAM) and extracellular matrix proteins (ECM) in various pathological processes including angiogenesis, thrombosis, apoptosis, cell migration & proliferation are well documented. These processes can lead to both acute and chronic disease states such as ocular diseases, metastasis, unstable angina, myocardial infarction, stroke, osteoporosis, a wide range of inflammatory diseases, vascular remodeling, and neurodegenerative disorders. A key success in this field is evident from the potential role of the platelet GPIIb/IIIa integrin in the prevention and diagnosis of various thromboembolic disorders. Additionally, the use of soluble adhesion molecules as potential diagnostic markers for acute and chronic leukocyte, platelet, and endothelial cellular insult are increasingly utilized. The development of various therapeutic and diagnostic candidates based on the key role of CAM, with special emphasis on integrins in various diseases as well as the structure-function aspects of cell adhesion and signaling of the different CAM and ECM are highlighted.
细胞黏附分子（CAM）和细胞外基质蛋白（ECM）在包括血管生成、血栓形成、细胞凋亡、细胞迁移和增殖在内的各种病理过程中的作用已有充分记载。这些过程可导致急性和慢性疾病状态，如眼部疾病、转移、不稳定型心绞痛、心肌梗死、中风、骨质疏松症、多种炎症性疾病、血管重塑和神经退行性疾病。血小板糖蛋白IIb/IIIa整合素在预防和诊断各种血栓栓塞性疾病中的潜在作用，清楚地表明了该领域的一项重大成就。此外，可溶性黏附分子作为急性和慢性白细胞、血小板及内皮细胞损伤潜在诊断标志物的应用也越来越广泛。基于细胞黏附分子的关键作用开发各种治疗和诊断候选物，特别强调整合素在各种疾病中的作用以及不同细胞黏附分子和细胞外基质蛋白的细胞黏附与信号传导的结构-功能方面。
