暴饮暴食症的家族性与遗传性：一项病例对照家庭研究和一项双生子研究的结果
Familiality and heritability of binge eating disorder: results of a case-control family study and a twin study.
作者信息
Javaras Kristin N, Laird Nan M, Reichborn-Kjennerud Ted, Bulik Cynthia M, Pope Harrison G, Hudson James I
机构信息
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.
出版信息
Int J Eat Disord. 2008 Mar;41(2):174-9. doi: 10.1002/eat.20484.
OBJECTIVE
To estimate the familiality and heritability of binge eating disorder (BED).
METHOD
We used a new ACE structural equation model to estimate heritability from a case-control family study of BED conducted in the Boston area. The sample consisted of 150 overweight/obese probands with lifetime BED by DSM-IV criteria, 150 overweight/obese probands without lifetime BED, and 888 of their first-degree relatives. We compared our findings with those from a study of binge eating (in the absence of compensatory behaviors) among 7,831 Norwegian twins.
RESULTS
The prevalence of BED differed by sex and by age. In the case-control family study, BED was found to aggregate in families, and heritability was estimated as 57% (CI: 30-77%). Including shared environment did not substantially improve the model's fit, nor did allowing sex-specific heritability. Findings from the twin study were similar.
CONCLUSION
BED appears to aggregate in families and have a significant genetic component.
目的
评估暴饮暴食症（BED）的家族聚集性和遗传性。
方法
我们使用一种新的ACE结构方程模型，从在波士顿地区进行的BED病例对照家族研究中估计遗传性。样本包括150名符合DSM-IV标准的终生患有BED的超重/肥胖先证者、150名无终生BED的超重/肥胖先证者以及他们的888名一级亲属。我们将研究结果与一项对7831名挪威双胞胎的暴饮暴食（无代偿行为）研究结果进行了比较。
结果
BED的患病率因性别和年龄而异。在病例对照家族研究中，发现BED在家族中聚集，遗传性估计为57%（CI：30 - 77%）。纳入共享环境并未显著改善模型拟合度，允许性别特异性遗传性也未改善。双胞胎研究的结果相似。
结论
BED似乎在家族中聚集且有显著的遗传成分。
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