Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado, USA.
Int J Eat Disord. 2024 Oct;57(10):2128-2134. doi: 10.1002/eat.24245. Epub 2024 Jun 28.
Pediatric loss-of-control (LOC) eating is associated with high BMI and predicts binge-eating disorder and obesity onset with age. Research on the etiology of this common comorbidity has not explored the potential for shared genetic risk. This study examined genetic and environmental influences on LOC eating and its shared influence with BMI.
Participants were 499 monozygotic and 398 same-sex dizygotic twins (age = 17.38 years ± 0.67, BMIz = 0.03 ± 1.03, 54% female) from the Colorado Center for Antisocial Drug Dependence Study. LOC eating was assessed dichotomously. Self-reported height and weight were converted to BMIz. Univariate and bivariate twin models estimated genetic and environmental influences on LOC eating and BMIz.
More girls (21%) than boys (9%, p < 0.001) reported LOC eating. The phenotypic correlation with BMIz was 0.03 in girls and 0.18 in boys. Due to the nonsignificant phenotypic correlation in girls, bivariate twin models were fit in boys only. Across all models, the best-fitting model included genetic and unique environmental effects. Genetic factors accounted for 0.51 (95% CI: 0.23, 0.73) of the variance of LOC eating in girls and 0.54 (0.18, 0.90) in boys. The genetic correlation between LOC eating and BMIz in boys was 0.45 (0.15, 0.75).
Findings indicate moderate heritability of LOC eating in adolescence, while emphasizing the role of unique environmental factors. In boys, LOC eating and BMIz share a proportion of their genetic influences.
儿童失控性进食（LOC）与高体重指数（BMI）有关，并预测随着年龄的增长暴食障碍和肥胖的发生。对这种常见共病病因的研究尚未探讨潜在的共同遗传风险。本研究考察了 LOC 进食及其与 BMI 的共同影响的遗传和环境影响。
参与者为来自科罗拉多反社会药物依赖研究中心的 499 对同卵双胞胎和 398 对同性别异卵双胞胎（年龄=17.38 岁±0.67，BMIz=0.03±1.03，54%为女性）。LOC 进食以二分法评估。自我报告的身高和体重转换为 BMIz。单变量和双变量双胞胎模型估计了 LOC 进食和 BMIz 的遗传和环境影响。
更多的女孩（21%）而不是男孩（9%，p<0.001）报告有 LOC 进食。与 BMIz 的表型相关性在女孩中为 0.03，在男孩中为 0.18。由于女孩的表型相关性不显著，因此仅在男孩中拟合双变量双胞胎模型。在所有模型中，最佳拟合模型包括遗传和独特环境效应。遗传因素占女孩 LOC 进食方差的 0.51（95%置信区间：0.23，0.73），占男孩的 0.54（0.18，0.90）。男孩 LOC 进食和 BMIz 之间的遗传相关性为 0.45（0.15，0.75）。
研究结果表明，青少年时期 LOC 进食具有中等程度的遗传性，同时强调了独特环境因素的作用。在男孩中，LOC 进食和 BMIz 具有共同的遗传影响。
