Hudson James I, Lalonde Justine K, Berry Judith M, Pindyck Lindsay J, Bulik Cynthia M, Crow Scott J, McElroy Susan L, Laird Nan M, Tsuang Ming T, Walsh B Timothy, Rosenthal Norman R, Pope Harrison G
Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Mass 02478, USA.
Arch Gen Psychiatry. 2006 Mar;63(3):313-9. doi: 10.1001/archpsyc.63.3.313.
Binge-eating disorder (BED)-a syndrome that only recently has attracted scientific attention-is often seen in obese individuals, especially those with severe obesity. However, it remains unclear whether BED represents an etiologically distinct behavioral phenotype of obesity or simply a nonspecific eating pattern sometimes seen in obese individuals.
To test whether BED aggregates in families independently of obesity, and if so, whether familial factors for BED also independently increase the risk of obesity.
DESIGN, PATIENTS, AND SETTING: Blinded family interview study of overweight or obese probands with (n = 150) and without (n = 150) BED, and their first-degree relatives (n = 888) in a community setting evaluated between October 2002 and July 2004.
Lifetime diagnosis of BED; current and highest lifetime body mass index (calculated as the weight in kilograms divided by the square of the height in meters).
Binge-eating disorder aggregated strongly in families independently of obesity (odds ratio, 2.2; 95% confidence interval, 1.4-3.6; P<.001). Furthermore, relatives of probands with BED displayed a markedly higher prevalence of severe obesity in adulthood (body mass index >/=40) than relatives of probands without BED even when controlling for proband body mass index (odds ratio, 2.5; 95% confidence interval, 1.4-4.4; P = .002).
Binge-eating disorder is a familial disorder caused in part by factors distinct from other familial factors for obesity. Furthermore, these BED-specific familial factors may independently increase the risk of obesity, especially severe obesity. It follows that targeted interventions capable of preventing or treating traits influenced by these BED-specific familial factors could reduce the public health burden of obesity.
暴饮暴食症（BED）——一种直到最近才引起科学关注的综合征——在肥胖个体中很常见，尤其是那些患有重度肥胖症的人。然而，暴饮暴食症是肥胖的一种病因独特的行为表型，还是仅仅是肥胖个体中有时会出现的一种非特异性饮食模式，目前尚不清楚。
测试暴饮暴食症在家庭中是否独立于肥胖而聚集，如果是，暴饮暴食症的家族因素是否也会独立增加肥胖风险。
设计、患者和研究地点：2002年10月至2004年7月期间，在社区环境中对150名患有暴饮暴食症和150名未患有暴饮暴食症的超重或肥胖先证者及其一级亲属（888名）进行了盲法家庭访谈研究。
暴饮暴食症的终生诊断；当前和最高终生体重指数（计算方法为体重千克数除以身高米数的平方）。
暴饮暴食症在家庭中强烈聚集，独立于肥胖（优势比为2.2；95%置信区间为1.4 - 3.6；P <.001）。此外，即使在控制了先证者体重指数的情况下，患有暴饮暴食症的先证者的亲属在成年期患重度肥胖症（体重指数≥40）的患病率仍明显高于未患有暴饮暴食症的先证者的亲属（优势比为2.5；95%置信区间为1.4 - 4.4；P = .002）。
暴饮暴食症是一种家族性疾病，部分由不同于其他肥胖家族因素的因素引起。此外，这些特定于暴饮暴食症的家族因素可能会独立增加肥胖风险，尤其是重度肥胖风险。因此能够预防或治疗受这些特定于暴饮暴食症的家族因素影响的特征的针对性干预措施可能会减轻肥胖对公共健康的负担。
