Deedwania Prakash, Srikanth Sundararajan
Department of Medicine, VACCHCS/UMC, UCSF Program at Fresno, 2615 E Clinton Ave, Fresno, CA 93703, USA.
Expert Rev Cardiovasc Ther. 2008 Jan;6(1):127-38. doi: 10.1586/14779072.6.1.127.
Type 2 diabetes has reached epidemic proportions and is now recognized as a coronary heart disease equivalent. While the most common metabolic abnormality associated with diabetes is hyperglycemia, there are also abnormalities in carbohydrate, fat and protein metabolism. These abnormalities increase oxidative stress and activate the renin-angiotensin system leading to endothelial dysfunction and, thereafter, to systemic atherosclerosis. This systemic atherosclerosis is responsible for the increased cardiovascular morbidity and mortality related to diabetes. In this article, we review the evidence and discuss the rationale for comprehensive risk reduction to prevent and treat vascular disease in individuals with diabetes mellitus. The components of comprehensive risk reduction strategy consist of lifestyle changes, glycemic control, control of dyslipidemia and hypertension.
2型糖尿病已呈流行态势，如今被视为等同于冠心病。虽然与糖尿病相关的最常见代谢异常是高血糖，但碳水化合物、脂肪和蛋白质代谢也存在异常。这些异常会增加氧化应激并激活肾素 - 血管紧张素系统，导致内皮功能障碍，进而引发全身性动脉粥样硬化。这种全身性动脉粥样硬化是糖尿病相关心血管发病率和死亡率增加的原因。在本文中，我们回顾了相关证据，并讨论了全面降低风险以预防和治疗糖尿病患者血管疾病的基本原理。全面降低风险策略的组成部分包括生活方式改变、血糖控制、血脂异常控制和高血压控制。
