de Bruijn Robert, Richardson Matt, Schagatay Erika
Department of Natural Sciences, Mid Sweden University, 851 70 Sundsvall, Sweden.
Eur J Appl Physiol. 2008 Mar;102(5):609-13. doi: 10.1007/s00421-007-0639-9. Epub 2007 Dec 19.
Hypoxia-induced increases in red blood cell production have been found in both altitude-adapted populations and acclimatized lowlanders. This process is mediated by erythropoietin (EPO) released mainly by the hypoxic kidney. We have previously observed high hemoglobin concentrations in elite breath-hold divers and our aim was to investigate whether apnea-induced hypoxia could increase EPO concentration. Ten healthy volunteers performed 15 maximal duration apneas, divided into three series of five apneas, each series separated by 10 min of rest. Apneas within series were separated by 2 min and preceded by 1 min of hyperventilation to increase apnea duration and arterial oxygen desaturation. When EPO concentration after serial apneas was compared to baseline values, an average maximum increase of 24% was found (P < 0.01). No changes in EPO concentration were observed during a control day without apnea, eliminating possible effects of a diurnal rhythm or blood loss. We therefore conclude that serial apneas increase circulating EPO concentration in humans.
在适应高原的人群和适应环境的低地人中，均发现低氧诱导的红细胞生成增加。这一过程由主要由缺氧肾脏释放的促红细胞生成素（EPO）介导。我们之前观察到精英屏气潜水员的血红蛋白浓度较高，我们的目的是研究呼吸暂停诱导的低氧是否会增加EPO浓度。10名健康志愿者进行了15次最大持续时间的呼吸暂停，分为三个系列，每个系列5次呼吸暂停，每个系列之间休息10分钟。系列内的呼吸暂停间隔2分钟，之前进行1分钟的过度通气以增加呼吸暂停持续时间和动脉血氧饱和度下降。将系列呼吸暂停后的EPO浓度与基线值进行比较时，发现平均最大增加24%（P < 0.01）。在没有呼吸暂停的对照日，未观察到EPO浓度的变化，排除了昼夜节律或失血的可能影响。因此，我们得出结论，系列呼吸暂停会增加人体循环中的EPO浓度。
