喉癌、肺癌、胃癌与早发性乳腺癌的家族关联性。

Familial association of laryngeal, lung, stomach and early-onset breast cancer.

作者信息

Jaworowska Ewa, Serrano-Fernández Pablo, Tarnowska Czesława, Lubiński Jakub, Brzosko Marek, Flicinski Jacek, Masojc Bartołomej, Matyjasik Joanna, Scott Rodney J, Narod Steven A, Lubiński Jan

机构信息

Department of Otolaryngology and Laryngological Oncology, Pomeranian Medical University, Szczecin, Poland.

出版信息

Breast Cancer Res Treat. 2008 Nov;112(2):359-61. doi: 10.1007/s10549-007-9869-0. Epub 2007 Dec 21.

DOI:10.1007/s10549-007-9869-0

PMID:18097745

Abstract

This study analyzes the incidence of different types of cancer among 2839 first-degree relatives of 760 consecutive, unselected laryngeal cancer patients, compared with the general population. A statistically significant excess was seen for other cancers of the larynx (SIR: 400), lung (SIR: 135) and stomach (SIR: 271), and early-onset breast cancer (SIR: 287). Familial laryngeal cancer may not be a single site-specific cancer syndrome.

摘要

本研究分析了760例未经挑选的连续性喉癌患者的2839名一级亲属中不同类型癌症的发病率，并与普通人群进行了比较。结果发现，喉的其他癌症（标化发病率：400）、肺癌（标化发病率：135）、胃癌（标化发病率：271）以及早发性乳腺癌（标化发病率：287）的发病率有统计学意义的显著升高。家族性喉癌可能不是一种单一部位特异性癌症综合征。