Familial association of laryngeal, lung, stomach and early-onset breast cancer.

作者信息

Jaworowska Ewa, Serrano-Fernández Pablo, Tarnowska Czesława, Lubiński Jakub, Brzosko Marek, Flicinski Jacek, Masojc Bartołomej, Matyjasik Joanna, Scott Rodney J, Narod Steven A, Lubiński Jan

机构信息

Department of Otolaryngology and Laryngological Oncology, Pomeranian Medical University, Szczecin, Poland.

出版信息

Breast Cancer Res Treat. 2008 Nov;112(2):359-61. doi: 10.1007/s10549-007-9869-0. Epub 2007 Dec 21.

DOI:10.1007/s10549-007-9869-0

PMID:18097745

Abstract

This study analyzes the incidence of different types of cancer among 2839 first-degree relatives of 760 consecutive, unselected laryngeal cancer patients, compared with the general population. A statistically significant excess was seen for other cancers of the larynx (SIR: 400), lung (SIR: 135) and stomach (SIR: 271), and early-onset breast cancer (SIR: 287). Familial laryngeal cancer may not be a single site-specific cancer syndrome.

摘要