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[胆囊切除术后医源性胆管损伤所致晚期胆管狭窄]

[Late stage stenoses of bile ducts after iatrogenic bile duct injuries following cholecystectomy].

作者信息

Bektas H, Winny M, Schrem H, Becker T, Klempnauer J

机构信息

Klinik für Allgemein, Viszeral- und Transplantationschirurgie, Medizinische Hochschule Hannover.

出版信息

Zentralbl Chir. 2007 Dec;132(6):523-8. doi: 10.1055/s-2007-981372.

Abstract

INTRODUCTION

Iatrogenic bile duct injuries represent a severe complication after cholecystectomy. For the attending physician therapy and management of these injuries are a challenge. Inadequate and delayed treatment can lead to stenoses at a late stage, which can necessitate further surgical intervention.

METHODS

In a study data of 74 patients, who were treated in our clinic for bile duct injuries following cholecystectomy, were analysed retrospectively.

RESULTS

A total of 8 patients with late stage bile duct strictures following iatrogenic bile duct injury including the subsequent therapy could be identified. The data of these patients were analysed in respect of cause and strategies to prevent late stage stenoses. In 62 patients the bile duct injury occurred following laparoscopic and in 12 patients following open cholecystectomy. In 16 patients the injury was combined with a vascular lesion. The interval between primary intervention and definitive therapy was 11 days in 53 patients and 1-15 years in 21 patients. In 8 patients the reason for the re-operation after a long interval (1-15 years) was a late stage stenosis. A hepatico-jejunostomy was performed subsequently and during follow-up 5 / 8 patients were symptom-free; 7 patients were re-operated due to a stenosed primary biliodigestive anastomosis and 3 patients each due to atrophy of the right liver lobe and recurrent cholangitis. One patient complained of recurrent cholangitis and a further patient of symptoms due to adhesions.

DISCUSSION

If treated inadequately bile duct injuries occurring during cholecystectomy can in the long-term lead to considerable problems such as recurrent cholangitis, late stage stenoses and even to secondary biliary cirrhosis. Therefore, a complex inter-disciplinary therapeutic concept aiming at timely treatment is necessary.

摘要

引言

医源性胆管损伤是胆囊切除术后的一种严重并发症。对于主治医生而言,这些损伤的治疗和管理是一项挑战。治疗不当和延误可导致后期出现狭窄,进而可能需要进一步的手术干预。

方法

回顾性分析在我院接受胆囊切除术后胆管损伤治疗的74例患者的数据。

结果

共识别出8例医源性胆管损伤后出现晚期胆管狭窄并包括后续治疗的患者。对这些患者的数据就晚期狭窄的原因和预防策略进行了分析。62例患者的胆管损伤发生在腹腔镜胆囊切除术后,12例发生在开腹胆囊切除术后。16例患者的损伤合并血管病变。初次干预与确定性治疗之间的间隔在53例患者中为11天,在21例患者中为1至15年。8例患者长时间间隔(1至15年)后再次手术的原因是晚期狭窄。随后进行了肝空肠吻合术,随访期间8例患者中有5例无症状;7例患者因初次胆肠吻合口狭窄再次手术,3例患者分别因右肝叶萎缩和复发性胆管炎再次手术。1例患者抱怨复发性胆管炎,另1例患者因粘连出现症状。

讨论

如果胆囊切除术中发生的胆管损伤治疗不当,长期来看可能会导致诸如复发性胆管炎、晚期狭窄甚至继发性胆汁性肝硬化等严重问题。因此,需要一个旨在及时治疗的复杂跨学科治疗理念。

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