Gallagher T K, Geoghegan J G, Baird A W, Winter D C
Institute of Clinical Outcomes in Research and Education (ICORE) Dublin, Republic of Ireland.
Obes Surg. 2007 Oct;17(10):1399-407. doi: 10.1007/s11695-007-9221-0.
The onset of obesity occurs as a result of an imbalance between nutrient consumption/absorption and energy expenditure. Gastrointestinal (GI) motility plays a critical role in the rate of consumption of foods, digestion, and absorption of nutrients. Various segments of the GI tract coordinate in a complex yet precise way, to control the process of food consumption, digestion, and absorption of nutrients. GI motility not only regulates the rates at which nutrients are processed and absorbed in the gut, but also, via mechanical and neurohormonal methods, participates in the control of appetite and satiety. Altered GI motility has frequently been observed in obese patients, the significance of which is incompletely understood. However, these alterations can be considered as potential contributing factors in the development and maintenance of obesity and changed eating behavior. Therapies aimed at regulating or counteracting the observed changes in GI motility are being actively explored and applied clinically in the management of obese patients.
肥胖的发生是营养物质消耗/吸收与能量消耗之间失衡的结果。胃肠（GI）蠕动在食物消耗速度、消化和营养物质吸收方面起着关键作用。胃肠道的各个部分以复杂而精确的方式协调，以控制食物消耗、消化和营养物质吸收的过程。胃肠蠕动不仅调节营养物质在肠道中被处理和吸收的速度，还通过机械和神经激素方式参与食欲和饱腹感的控制。肥胖患者中经常观察到胃肠蠕动改变，但其意义尚未完全明确。然而，这些改变可被视为肥胖发展和维持以及饮食行为改变的潜在促成因素。旨在调节或抵消所观察到的胃肠蠕动变化的疗法正在积极探索中，并在肥胖患者的管理中临床应用。
