van Aswegen C H, du Plessis D J
Department of Urology, University of Pretoria, South Africa.
Med Hypotheses. 1991 Dec;36(4):368-70. doi: 10.1016/0306-9877(91)90011-m.
Although many risk factors and theories exist in the literature for urinary stone formation, a hypothesis is suggested for the pathogenesis of renal stones. According to the matrix theory, a protein such as uromucoid activates the initial crystallisation process by promoting the formation of calcium oxalate and calcium phosphate crystals as well as clumping in whole urine. We put forward a theory whereby one of the most important factors in the matrix theory would be the composition and concentration of the protein. In support of this hypothesis, emphasis is placed on the activities of urokinase and sialidase.
尽管文献中有许多关于尿石形成的危险因素和理论，但本文提出了一种肾结石发病机制的假说。根据基质理论，诸如尿类粘蛋白之类的蛋白质通过促进草酸钙和磷酸钙晶体的形成以及在全尿中的聚集来激活初始结晶过程。我们提出一种理论，即基质理论中最重要的因素之一是蛋白质的组成和浓度。为支持这一假说，重点关注了尿激酶和唾液酸酶的活性。
