du Toit P J, Van Aswegen C H, Steinmann C M, Klue L, Du Plessis D J
Department of Physiology, University of Pretoria, South Africa.
Med Hypotheses. 1997 Jul;49(1):57-9. doi: 10.1016/s0306-9877(97)90253-x.
Renal stone formation is a complex multifactorial disease, and it is believed that the initial step in the pathogenesis of urolithiasis must be the precipitation of an organic matrix of mucoproteins followed by precipitation of minerals onto this matrix. An important factor in this process may be the activity and/or concentration of the urinary enzyme, urokinase, which would affect the level of urinary mucoproteins such as uromucoid. In support of this hypothesis, ELISA studies were conducted to investigate the urokinase concentrations in urine obtained from males (22-60 years) with and without renal stones. These results showed a significant decrease in urinary urokinase concentration of renal stone patients which, once again, underlines the possible involvement of urokinase in renal stone formation. Therefore, it seems logical to conclude that urokinase may play an integral role in this multifactorial disease.
肾结石形成是一种复杂的多因素疾病，人们认为尿石症发病机制的初始步骤必定是粘蛋白有机基质的沉淀，随后矿物质在该基质上沉淀。此过程中的一个重要因素可能是尿酶尿激酶的活性和/或浓度，它会影响尿粘蛋白如尿类粘蛋白的水平。为支持这一假说，进行了酶联免疫吸附测定（ELISA）研究，以调查从有和没有肾结石的男性（22 - 60岁）获取的尿液中的尿激酶浓度。这些结果显示，肾结石患者的尿尿激酶浓度显著降低，这再次强调了尿激酶可能参与肾结石形成。因此，得出尿激酶可能在这种多因素疾病中起不可或缺作用的结论似乎是合理的。
