Baggio B, Gambaro G, Favaro S, Borsatti A, Pavanello L, Siviero B, Zacchello G, Rizzoni G F
J Urol. 1983 Dec;130(6):1133-5. doi: 10.1016/s0022-5347(17)51721-8.
Urinary excretion of the most widely studied renal stone promoting (calcium, oxalate, uric acid and phosphate) and inhibiting (citrate, magnesium, pyrophosphate and glycosaminoglycans) factors, as well as the Tamm-Horsfall mucoprotein, was evaluated in 14 children with idiopathic calcium nephrolithiasis, 6 children with renal stone disease secondary to excretory malformations and 19 normal controls. No statistically significant differences in urinary excretion of promoting and inhibiting factors were found in children with idiopathic calcium nephrolithiasis but the relationship between promoting and inhibiting factors was changed as shown by an abnormal ratio of oxalate/citrate X glycosaminoglycans. This finding suggests that there is an imbalance between promoting and inhibiting factors in children with idiopathic calcium nephrolithiasis, and it is not detected by assay of each single substance.
在14例特发性钙肾结石患儿、6例继发于排泄畸形的肾结石病患儿和19名正常对照者中，对研究最广泛的促进肾结石形成（钙、草酸盐、尿酸和磷酸盐）和抑制肾结石形成（柠檬酸盐、镁、焦磷酸盐和糖胺聚糖）的因子以及Tamm-Horsfall黏蛋白的尿排泄情况进行了评估。在特发性钙肾结石患儿中，促进和抑制因子的尿排泄未发现统计学上的显著差异，但促进和抑制因子之间的关系发生了变化，表现为草酸盐/柠檬酸盐X糖胺聚糖的比例异常。这一发现表明，特发性钙肾结石患儿中促进和抑制因子之间存在失衡，且通过对每种单一物质的检测无法检测到这种失衡。
