Shirouzu K, Isomoto H, Morodomi T, Araki Y, Kakegawa T
First Department of Surgery, Kurume University School of Medicine, Japan.
Nihon Geka Gakkai Zasshi. 1991 Dec;92(12):1686-93.
To evaluate lymphatic permeation as a prognostic factor in colorectal cancer, long-term prospective studies were conducted and the following results were obtained. 1) The degree of lymphatic permeation increased as the depth of invasion, lymph node metastasis, and stage advanced. 2) Moderate or marked lymphatic permeation (ly2 or ly3) was observed at a high rate in moderately and poorly differentiated adenocarcinoma. 3) Recurrence was more common in the patients with ly2 or ly3. 4) In stage 2 and 3 patients with slight plus no lymphatic permeation (ly0 or ly1), the seven-year survival rates were 89.8% and 85.6%, respectively. In the ly2 + ly3 group, the rates were 67.1% and 66.1%, respectively and a significant difference was noted. In stage 4, however, there was no significant difference between the two groups. Conclusions were as follows. 1) The degree of lymphatic permeation was considered to be extremely closely related to the progression of cancer, histological type and recurrence. 2) In stage 2 and stage 3, the degree of lymphatic permeation was an important prognostic factor, but in stage 4 it was not. 3) It was shown that lymphatic permeation as classified by the authors was a reliable index for survival rates.
为评估淋巴渗透作为结直肠癌预后因素的作用，开展了长期前瞻性研究并获得以下结果。1）淋巴渗透程度随浸润深度、淋巴结转移及分期进展而增加。2）在中分化和低分化腺癌中，中度或显著淋巴渗透（ly2或ly3）的发生率较高。3）ly2或ly3患者的复发更为常见。4）在2期和3期伴有轻度加无淋巴渗透（ly0或ly1）的患者中，七年生存率分别为89.8%和85.6%。在ly2 + ly3组中，七年生存率分别为67.1%和66.1%，差异有统计学意义。然而，在4期，两组之间无显著差异。结论如下。1）淋巴渗透程度被认为与癌症进展、组织学类型及复发密切相关。2）在2期和3期，淋巴渗透程度是一个重要的预后因素，但在4期则不是。3）结果表明，作者所分类的淋巴渗透是生存率的可靠指标。
