Fabrikov A P, Dorofeeva S D, Shishkina S N
Ter Arkh. 1991;63(11):25-7.
RIA was used to measure the content of insulin, C-peptide and glucagon in blood plasma of 84 patients with acute dysentery and food toxicoinfections. The studies were carried out in the acute disease period and before the discharge from hospital. The data obtained indicate that despite the appreciable differences in the disease pathogenesis, the pathophysiological mechanisms influencing pancreatic function are similar in many respects. The changes are characterized by an increase in plasma insulin and a reduction in C-peptide and glucagon. The content of hormones in the peripheral blood is dependent on the disease period. In the authors' opinion, despite the high insulin content, the reduced level of C-peptide attests to hypofunction of beta-cells in acute intestinal infection, since it reflects their function more precisely. The reduced content of plasma glucagon points to hypofunction of alpha-cells.
采用放射免疫分析法（RIA）测定了84例急性痢疾和食物中毒性感染患者血浆中胰岛素、C肽和胰高血糖素的含量。研究在急性期及出院前进行。所得数据表明，尽管疾病发病机制存在明显差异，但影响胰腺功能的病理生理机制在许多方面是相似的。这些变化的特点是血浆胰岛素升高，C肽和胰高血糖素降低。外周血中激素含量取决于疾病阶段。作者认为，尽管胰岛素含量高，但C肽水平降低证明急性肠道感染时β细胞功能减退，因为它能更准确地反映β细胞的功能。血浆胰高血糖素含量降低表明α细胞功能减退。
