Kétyi I
Institute of Microbiology, University Medical School, Pécs, Hungary.
Acta Microbiol Hung. 1991;38(1):33-41.
An artificial monoflora of Escherichia coli in mice, as well as their autochtonous E. coli, exhibited enhanced resistance to streptomycin, chloramphenicol, sodium hypochlorite and silver nitrate. The level of resistance of the monoflora, which was 10-32 times higher than the in vitro determined Minimal Bactericidal Dose (MBCD), reached its maximum on the 7th-9th day after implantation. This latency is a requirement for the stabilization of the monoflora. Formaldehyde and carbenicillin were equally effective in the planktonic and in the biofilm mode of growth. In the case of carbenicillin the pieces of mouse colon contained about 60% of the dose used for exposure, in contrast to the 3% rate of streptomycin, showing the excellent penetrating ability of carbenicillin into the intestinal biofilm.
小鼠体内的大肠杆菌人工单菌群落及其自身的大肠杆菌对链霉素、氯霉素、次氯酸钠和硝酸银均表现出增强的抗性。单菌群落的抗性水平比体外测定的最小杀菌剂量（MBCD）高10至32倍，在植入后第7至9天达到最大值。这种潜伏期是单菌群落稳定的必要条件。甲醛和羧苄青霉素在浮游生长模式和生物膜生长模式下同样有效。就羧苄青霉素而言，小鼠结肠组织中含有约60%的暴露剂量，而链霉素的这一比例为3%，这表明羧苄青霉素对肠道生物膜具有出色的穿透能力。
