抑制血栓素形成作为3,4 - 二羟基氧杂蒽酮和五乙酸槲皮素的抗血小板机制。
Inhibition of thromboxane formation as the antiplatelet mechanism of 3,4-dihydroxyxanthone and quercetin pentaacetate.
作者信息
Lin H C, Liu H W, Lin C N, Teng C M
机构信息
School of Technology for Medical Sciences, Kaohsiung Medical College, Taiwan, Republic of China.
出版信息
Gaoxiong Yi Xue Ke Xue Za Zhi. 1991 Oct;7(10):505-12.
3,4-Dihydroxyxanthone and quercetin pentaacetate were shown to inhibit the aggregation and ATP release of washed rabbit platelets induced by collagen and arachidonic acid, but were not induced by PAF. This inhibition was reversible and in a concentration-dependent manner. The thromboxane B2 formation of washed rabbit platelets, which was caused by arachidonic acid and collagen, was also suppressed by both antiplatelet agents. In human platelet-rich plasma, 3,4-dihydroxyxanthone and quercetin pentaacetate inhibited the secondary, but not the primary aggregation induced by ADP and epinephrine. Both antiplatelet agents also inhibited collagen- and arachidonic acid-induced aggregation in whole blood in a dose-dependent manner. It is concluded that the antiplatelet effects of 3,4-dihydroxyxanthone and quercetin pentaacetate are due to the inhibition of thromboxane formation.
3,4-二羟基呫吨酮和槲皮素五乙酸酯可抑制胶原和花生四烯酸诱导的洗涤兔血小板聚集及ATP释放，但PAF不能诱导其产生这种作用。这种抑制是可逆的且呈浓度依赖性。两种抗血小板药物还可抑制由花生四烯酸和胶原引起的洗涤兔血小板血栓素B2的生成。在富含人血小板的血浆中，3,4-二羟基呫吨酮和槲皮素五乙酸酯可抑制ADP和肾上腺素诱导的继发性聚集，但不能抑制原发性聚集。两种抗血小板药物还可剂量依赖性地抑制全血中胶原和花生四烯酸诱导的聚集。结论是，3,4-二羟基呫吨酮和槲皮素五乙酸酯的抗血小板作用是由于抑制了血栓素的形成。
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