McDonald W M, Krishnan K R, Doraiswamy P M, Blazer D G
Department of Psychiatry, Duke University, Durham, NC.
Psychiatry Res. 1991 Dec;40(4):211-20. doi: 10.1016/0925-4927(91)90013-g.
In a retrospective study, brain magnetic resonance images of 12 patients with the onset of manic symptoms after the age of 50 years were compared to age- and sex-matched control subjects for the incidence, size, and location of subcortical hyperintensities. Compared with controls, the patients demonstrated a significantly greater number of large subcortical hyperintensities, particularly in the middle third of the brain parenchyma. The lesions occurred with equal frequency in the right and left hemisphere. There were no differences between the two groups in the size of the ventricles or the presence of periventricular hyperintensities.
在一项回顾性研究中，将12例50岁以后出现躁狂症状患者的脑磁共振图像与年龄和性别匹配的对照受试者进行比较，以观察皮质下高信号的发生率、大小和位置。与对照组相比，患者皮质下大高信号的数量明显更多，尤其是在脑实质的中三分之一处。病变在右半球和左半球出现的频率相同。两组在脑室大小或脑室周围高信号的存在方面没有差异。
