Gonzalez-Vitale J C, Slavin R E, McQueen J D
Cancer. 1976 Jun;37(6):2960-3. doi: 10.1002/1097-0142(197606)37:6<2960::aid-cncr2820370653>3.0.co;2-2.
An autopsy case of radiation-induced intracranial malignant fibrous histiocytoma (fibroxanthosarcoma) is reported. The tumor developed in the region of the sella turcica 11 years after high dose radiotherapy of a chromophobe adenoma of the pituitary. The tumor had infiltrated the base of the brain as well as the base of the skull. Metastases were not found. The tumor was composed of an admixture of bizarre fibroblasts, histiocytes and giant cells, xanthoma cells and siderophages, with a storiform fibrous stroma. This appears to be the first documented instance of a malignant fibrous histiocytoma occurring intracranially after local x-irradiation.
报告一例放射性颅内恶性纤维组织细胞瘤（纤维黄色肉瘤）尸检病例。该肿瘤发生于垂体嫌色性腺瘤高剂量放疗11年后的蝶鞍区。肿瘤已浸润至脑底部及颅底部。未发现转移。肿瘤由奇异的成纤维细胞、组织细胞和巨细胞、黄色瘤细胞及含铁血黄素吞噬细胞混合组成，伴有束状纤维性间质。这似乎是局部X线照射后颅内发生恶性纤维组织细胞瘤的首例有文献记载的病例。
