Ko J Y, Chen C L, Lui L T, Hsu M M
Department of Otolaryngology, National Taiwan University Hospital, Taipei.
Arch Otolaryngol Head Neck Surg. 1996 May;122(5):535-8. doi: 10.1001/archotol.1996.01890170067013.
To evaluate the prevalence, 15-year cumulative incidence, time interval, and prognosis of radiation-induced malignant fibrous histiocytoma of the head and neck in long-term survivors of nasopharyngeal carcinoma.
Cohort.
Tertiary care hospital.
Eight long-term survivors of nasopharyngeal carcinoma with malignant fibrous histiocytoma in the maxillary sinus or nasal cavity.
Survival of postirradiation malignant fibrous histiocytoma in patients with nasopharyngeal carcinoma.
The prevalence of radiation-induced malignant fibrous histiocytoma in long-term survivors of nasopharyngeal carcinoma was 0.38%. The 15-year cumulative incidence was 2.2%. Most tumors occurred in the maxillary sinus and were characterized by spindle-shaped tumor cells with plump nuclei arranged in a whorl or storiform pattern in a fibrous stroma. The mean interval between malignant fibrous histiocytoma and nasopharyngeal carcinoma was 121 months. Local recurrence developed in all cases within 9 months after surgery. Six patients died of disease without distant metastasis within 30 months. Two patients were alive with disease for 20 and 32 months, respectively.
Radiation-induced malignant fibrous histiocytoma in the head and neck region in long-term survivors of nasopharyngeal carcinoma is rare. It takes a long time to occur after irradiation and is locally invasive with poor prognosis.
评估鼻咽癌长期存活者头颈部放射性诱发恶性纤维组织细胞瘤的患病率、15年累积发病率、时间间隔及预后情况。
队列研究。
三级护理医院。
8例鼻咽癌长期存活者，其在上颌窦或鼻腔发生恶性纤维组织细胞瘤。
鼻咽癌患者放疗后恶性纤维组织细胞瘤的生存率。
鼻咽癌长期存活者中放射性诱发恶性纤维组织细胞瘤的患病率为0.38%。15年累积发病率为2.2%。多数肿瘤发生在上颌窦，其特征为梭形肿瘤细胞，细胞核饱满，在纤维基质中呈漩涡状或席纹状排列。恶性纤维组织细胞瘤与鼻咽癌之间的平均间隔时间为121个月。所有病例术后9个月内均出现局部复发。6例患者无远处转移，在30个月内死于疾病。2例患者分别带瘤存活20个月和32个月。
鼻咽癌长期存活者头颈部放射性诱发恶性纤维组织细胞瘤罕见。放疗后发生时间较长，具有局部侵袭性，预后较差。
