Lee S C, Henry M M, Gonzalez-Crussi F
Cancer. 1976 Jul;38(1):249-53. doi: 10.1002/1097-0142(197607)38:1<249::aid-cncr2820380137>3.0.co;2-d.
A case is described of heterotopic brain tissue with simultaneous occurrence of melanotic neuroectodermal tumor in the oropharynx of a 6-week-old infant. The melanotic neuroectodermal tumor was embedded within the heterotopic glial tissue. This coexistence leads us to speculate that a defect causing a pinching-off of both neural crest cap and medullary epithelium of neural tube might have taken place at, or before, the 25-30 somite stage. The displaced embryonic structures subsequently differentiated into glial tissue, choroid plexus, and melanotic neuroectodermal tumor. This observation may be interpreted as further support in favor of a neural crest origin of juvenile melanotic neuroectodermal tumor.
本文描述了一例6周龄婴儿口咽部位异位脑组织同时合并黑素性神经外胚层肿瘤的病例。黑素性神经外胚层肿瘤包埋于异位的神经胶质组织内。这种共存情况使我们推测，在25 - 30体节期或之前，可能发生了导致神经管神经嵴帽和髓上皮被挤压分离的缺陷。移位的胚胎结构随后分化为神经胶质组织、脉络丛和黑素性神经外胚层肿瘤。这一观察结果可被视为支持青少年黑素性神经外胚层肿瘤起源于神经嵴的进一步证据。
