Stöhlmacher P
Institut für Rechtsmedizin, Universität Rostock.
Beitr Gerichtl Med. 1991;49:143-7.
The enzyme systems aldehyde dehydrogenase (ALDH), formaldehyde dehydrogenase (FDH) and S-formylglutation dehydrogenase (FGH/ESD) were investigated in specimen of cadaveric liver and brain by semiquantitative adjusted starch gel electrophoresis. Two groups of autopsy cases were compaired 1. alcoholics with fatty liver and 2. nonalcoholics. In ALDH and FDH there were no differences between the examined groups. In about 48% of specimens of alcoholics were in a more or less degree alterations in phenotypes of ESD detectable in vitro experiments showed that ESD spots were modified and became less intensive in the presence of formaldehyde (0.5-2.5 mg/g). These alterations were more intensiv in the phenotyp ESD 1 then in the phenotyp ESD 2-1.
通过半定量调整淀粉凝胶电泳法，对尸体肝脏和大脑标本中的醛脱氢酶（ALDH）、甲醛脱氢酶（FDH）和S-甲酰谷胱甘肽脱氢酶（FGH/ESD）酶系统进行了研究。比较了两组尸检病例：1. 患有脂肪肝的酗酒者；2. 非酗酒者。在ALDH和FDH方面，检查的两组之间没有差异。在大约48%的酗酒者标本中，ESD表型或多或少存在改变。体外实验表明，在甲醛（0.5-2.5毫克/克）存在的情况下，ESD条带发生改变且强度减弱。这些改变在ESD 1表型中比在ESD 2-1表型中更明显。
