人类酗酒者与对照者的脑醛脱氢酶

Brain aldehyde dehydrogenase in human alcoholics and controls.

作者信息

Pietruszko R, Reed D M, Vallari R C, Major L F, Saini N, Hawley R J

出版信息

Alcohol Clin Exp Res. 1981 Jan;5(1):78-84. doi: 10.1111/j.1530-0277.1981.tb04869.x.

DOI:10.1111/j.1530-0277.1981.tb04869.x

Abstract

Human postmortem brain samples from temporal lobe of 23 alcoholics and 19 controls (13 with cancer and six without cancer) were used for determination of low Km (micromolar) and high Km (millimolar) aldehyde dehydrogenase activity. Despite histories of severe alcoholism leading to death through multiple complications, the mean values for either low or high Km activity did not differ significantly from that of controls similarly studied.

摘要

取自23名酗酒者和19名对照者（13名患癌症，6名未患癌症）颞叶的人类尸检脑样本用于测定低Km（微摩尔）和高Km（毫摩尔）醛脱氢酶活性。尽管有严重酗酒史并因多种并发症导致死亡，但低Km或高Km活性的平均值与同样接受研究的对照者相比并无显著差异。