Marrero Arroyo D, Carrer M T, Molina M, Gómez M, Jiménez E
Departamento de Pediatría, Hospital de la Capital.
Bol Asoc Med P R. 1991 Dec;83(12):530-4.
The response to sublingual nifedipina was observed in 7 pediatric patients with renal disease and acute severe hypertension. Average dose used was 0.21 mg/kg, and an initial rapid response was evidenced as early as 3 minutes post administration. The greatest hypotensive effect was seen during the first 30 minutes, but continued its effect up to 60-120 minutes. The drug was well tolerated, of rapid action and results suggests it is efficient in the management of children and adolescents with acute secondary hypertension. No mayor adverse effects were encountered.
对7例患有肾脏疾病和急性重度高血压的儿科患者观察了舌下含服硝苯地平的反应。平均使用剂量为0.21mg/kg,给药后3分钟即出现早期快速反应。最大降压作用出现在最初30分钟内,但作用持续至60 - 120分钟。该药物耐受性良好,起效迅速,结果表明它在治疗儿童和青少年急性继发性高血压方面有效。未遇到重大不良反应。