Pérez C, Dougnac A, Alvarez M, Andresen M, Díaz O, Geni R, Prat G, Vásquez M
Departamento de Medicina Interna, Hospital Clínico Pontificia Universidad Católica de Chile.
Rev Med Chil. 1991 Apr;119(4):402-5.
The currently accepted drug of choice for treatment of hypertensive crisis is sublingual nifedipine. We compared the effects of sublingual captopril (25 mg) to those of nifedipine (10 mg) in 54 patients with this complication who came to the emergency room. Five min after administration of captopril, blood pressure decreased from 197.5 +/- 32.7/118.3 +/- 8.2 to 156 +/- 27.2/95.8 +/- 12.9 mmHg and heart rate decreased from 87.9 +/- 15.1 to 74.7 +/- 10.9 (p < 0.05). Blood pressure in the nifedipine group decreased from 198 +/- 27.3/120 +/- 9.8 to 147.7 +/- 17.8/86 +/- 17.9 (p < 0.05), while no change was observed in heart rate. Delayed measurements showed lower diastolic pressures at 60 and 75 min and lower systolic pressure at 120 min in the nifedipine group (p < 0.054). Few and not significantly different side effects were observed with both drugs. Thus, sublingual captopril is useful for treatment of hypertensive crisis.
目前公认的治疗高血压危象的首选药物是舌下含服硝苯地平。我们比较了舌下含服卡托普利（25毫克）和硝苯地平（10毫克）对54例前来急诊室就诊的该并发症患者的疗效。服用卡托普利5分钟后，血压从197.5±32.7/118.3±8.2降至156±27.2/95.8±12.9毫米汞柱，心率从87.9±15.1降至74.7±10.9（p<0.05）。硝苯地平组血压从198±27.3/120±9.8降至147.7±17.8/86±17.9（p<0.05），而心率无变化。延迟测量显示，硝苯地平组在60和75分钟时舒张压较低，在120分钟时收缩压较低（p<0.054）。两种药物观察到的副作用很少且无显著差异。因此，舌下含服卡托普利对治疗高血压危象有效。
