Josephson L, Bigler J, White D
Advanced Magnetics, Inc., Cambridge, Massachusetts 02138.
Magn Reson Med. 1991 Dec;22(2):204-8; discussion 213-5. doi: 10.1002/mrm.1910220208.
We have compared the magnetic properties of various types of materials known to affect MR images. The materials compared were: (i) MR contrast agents based on chelates of paramagnetic metals (Gd-DTPA, Dy-DTPA); (ii) biological forms of iron (horse spleen ferritin and deoxyhemoglobin); and (iii) a superparamagnetic iron oxide (AMI-25). The properties compared were the magnetic susceptibility and the magnetization. The magnetization and susceptibility of superparamagnetic AMI-25 are far larger than that of ferritin or low molecular weight, paramagnetic chelates. Superparamagnetic iron oxide colloids, like AMI-25, are a uniquely powerful class of magnetic materials.
我们比较了已知会影响磁共振成像的各类材料的磁特性。所比较的材料有：(i) 基于顺磁性金属螯合物的磁共振造影剂（钆 - 二乙三胺五乙酸、镝 - 二乙三胺五乙酸）；(ii) 铁的生物形态（马脾铁蛋白和脱氧血红蛋白）；以及(iii) 一种超顺磁性氧化铁（AMI - 25）。所比较的特性为磁化率和磁化强度。超顺磁性的 AMI - 25 的磁化强度和磁化率远大于铁蛋白或低分子量顺磁性螯合物。像 AMI - 25 这样的超顺磁性氧化铁胶体是一类独特的强磁性材料。
