Høiby E A, Bjune G, Frøholm L O, Eng J, Halstensen A, Rosenqvist E, Rønnild E, Wedege E
Department of Bacteriology, National Institute of Public Health, Oslo.
NIPH Ann. 1991 Dec;14(2):107-21; discussion 121-3.
A survey is given of the efforts made to inform the general public, the potential vaccinees and their parents, and the health care personnel about meningococcal disease in general and the vaccination trial in particular, as a preparation for the meningococcal outer membrane vesicle serogroup B vaccine (MenB-vaccine "Folkehelsa") trials in secondary school students and military conscripts in Norway. Our case reporting system, supplementing the official notification, concerning even vaguely suspected cases in the age cohorts involved, is described. The efforts made to collect clinical material as well as laboratory and clinical data from 221 registered suspected cases are delineated. We also briefly summarize our cerebrospinal fluid antigen detection methods and diagnostic meningococcal serology work on these suspected cases. The compiled information on findings done at the admitting hospital of the possible cases and the additional diagnostic data provided at the National Institute of Public Health were put at the disposal of the independent Diagnosis Review Committee (DRC) as a basis for their diagnostic decisions before code opening for the meningococcal serogroup B outer membrane vesicle vaccine protection trial 3 June 1991.
本文介绍了为向公众、潜在的疫苗接种者及其父母以及医护人员普及脑膜炎球菌疾病，特别是疫苗接种试验所做的努力，以此作为在挪威中学生和应征入伍军人中开展B群脑膜炎球菌外膜囊泡疫苗（MenB疫苗“Folkehelsa”）试验的准备工作。描述了我们的病例报告系统，该系统补充了官方通报，涉及相关年龄组中哪怕是疑似程度很模糊的病例。阐述了为从221例登记的疑似病例中收集临床材料以及实验室和临床数据所做的努力。我们还简要总结了针对这些疑似病例的脑脊液抗原检测方法和诊断性脑膜炎球菌血清学工作。在1991年6月3日B群脑膜炎球菌外膜囊泡疫苗保护试验揭盲前，将在收治可能病例的医院所做的检查结果以及国家公共卫生研究所提供的额外诊断数据汇编而成的信息，提供给独立诊断审查委员会（DRC），作为其诊断决策的依据。
