Høiby E A, Rosenqvist E, Frøholm L O, Bjune G, Feiring B, Nøkleby H, Rønnild E
Department of Bacteriology, National Institute of Public Health, Oslo.
NIPH Ann. 1991 Dec;14(2):147-55; discussion 155-6.
Results from the serum bactericidal assay (BA) after immunization of human volunteers with the Norwegian serogroup B meningococcal outer membrane vesicle vaccine are surveyed. In the phase II trials with adults we found very high seroconversion rates (greater than 98%) against the vaccine strain in the BA. Details in the antigenic composition of the inoculum used in the BA seem very important as shown here by finding lower bactericidal titres with teenager sera when tested with a variant of the standard inoculum. The present preliminary report corresponds to the presentation given at the Report Meeting on the Norwegian Meningococcal Vaccine Trial, Oslo, 12 September, 1991.
对挪威B群脑膜炎球菌外膜囊泡疫苗免疫人类志愿者后的血清杀菌试验（BA）结果进行了调查。在成人的II期试验中，我们发现BA中针对疫苗株的血清转化率非常高（大于98%）。正如在此所显示的，当用标准接种物的变体对青少年血清进行测试时，BA中使用的接种物的抗原组成细节似乎非常重要，因为此时杀菌效价较低。本初步报告与1991年9月12日在奥斯陆举行的挪威脑膜炎球菌疫苗试验报告会上的发言一致。
