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在丰富或贫瘠环境中饲养的大鼠大脑中环状AMP反应的改变。

Altered brain cyclic AMP-responses in rats reared in enriched or impoverished environments.

作者信息

Dismukes R K, Daly J W

出版信息

Experientia. 1976 Jun 15;32(6):730-2. doi: 10.1007/BF01919858.

DOI:10.1007/BF01919858
PMID:181268
Abstract

The accumulation of radioactive cyclic AMP elicited by various neurohormones has been examined in adenine-labeled telencephalon slices from rats raised in enriched or impoverished environments. Basal levels of cyclic AMP and responses of the brain slice cyclic AMP-generating systems to norepinephrine, isoproterenol and adenosine did not differ between the two group of rats, while responses to prostaglandin E1 were significantly greater with the impoverished group and responses to histamine appeared to be greater with the enriched group.

摘要

在分别饲养于丰富环境或贫瘠环境的大鼠的腺嘌呤标记端脑切片中，研究了各种神经激素引发的放射性环磷酸腺苷（cAMP）的积累情况。两组大鼠的环磷酸腺苷基础水平以及脑切片中环磷酸腺苷生成系统对去甲肾上腺素、异丙肾上腺素和腺苷的反应并无差异，而贫瘠组对前列腺素E1的反应显著更强，丰富组对组胺的反应似乎更强。

相似文献

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Altered brain cyclic AMP-responses in rats reared in enriched or impoverished environments.在丰富或贫瘠环境中饲养的大鼠大脑中环状AMP反应的改变。
Experientia. 1976 Jun 15;32(6):730-2. doi: 10.1007/BF01919858.
2
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The noradrenergic cyclic AMP generating system in the limbic forebrain: pharmacological characterization in vitro and possible role of limbic noradrenergic mechanisms in the mode of action of antipsychotics.边缘前脑去甲肾上腺素能环磷酸腺苷生成系统：体外药理学特性及边缘去甲肾上腺素能机制在抗精神病药物作用方式中的可能作用
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本文引用的文献

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A highly sensitive adenylate cyclase assay.一种高灵敏度的腺苷酸环化酶检测方法。
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The pineal gland: a neurochemical transducer.松果体：一种神经化学换能器。
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Accumulation of adenosine cyclic 3',5'-monophosphate in rat cerebral cortical slices. Stimulatory effect of alpha and beta adrenergic agents after treatment with 6-hydroxydopamine, 2,3,5-trihydroxyphenethylamine, and dihydroxytryptamines.大鼠大脑皮质切片中3',5'-环磷酸腺苷的积累。用6-羟基多巴胺、2,3,5-三羟基苯乙胺和二羟基色胺处理后α和β肾上腺素能药物的刺激作用。
Mol Pharmacol. 1973 Nov;9(6):711-7.
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Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain.各种抗抑郁治疗的作用可降低边缘前脑去甲肾上腺素能环磷酸腺苷生成系统的反应性。
Nature. 1975 Oct 9;257(5526):495-6. doi: 10.1038/257495a0.
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Accumulation of adenosine 3',5'-monophosphate in rat brain slices: effects of prostaglandins.大鼠脑切片中3',5'-单磷酸腺苷的积累：前列腺素的影响
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