Zukowska-Szczechowska E, Wocial B, Grzeszczak W, Kokot F
Department of Nephrology, Silesian School of Medicine, Katowice, Poland.
Mater Med Pol. 1989 Jul-Sep;21(3):160-4.
Water immersion (WI) induced alterations of adrenaline and noradrenaline levels were examined in 20 patients with chronic renal failure (CRF) and 15 healthy persons. In patients with CRF a significantly elevated mean arterial blood pressure (MAP), a markedly elevated plasma level of adrenaline but only a slightly elevated concentration of plasma noradrenaline were observed as compared with healthy persons. In all examined groups WI induced significant decrease of mean arterial pressure and plasma adrenaline and noradrenaline levels. In patients with CRF the WI induced a decrease of MAP and of plasma adrenaline was significantly more marked, while that of plasma noradrenaline was significantly less than in healthy persons. Results presented in this study suggest the existence of an impaired function of the sympathetic nervous system, mainly of the beta-adrenergic one in CRF.
对20例慢性肾衰竭（CRF）患者和15名健康人进行了水浸（WI）诱导的肾上腺素和去甲肾上腺素水平变化的研究。与健康人相比，CRF患者平均动脉血压（MAP）显著升高，血浆肾上腺素水平明显升高，但血浆去甲肾上腺素浓度仅略有升高。在所有检查组中，WI均导致平均动脉压以及血浆肾上腺素和去甲肾上腺素水平显著降低。在CRF患者中，WI诱导的MAP和血浆肾上腺素的降低更为显著，而血浆去甲肾上腺素的降低则明显低于健康人。本研究结果提示CRF患者存在交感神经系统功能受损，主要是β-肾上腺素能系统功能受损。
