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1
Elaboration of toxic oxygen by-products by neutrophils in a model of immune complex disease.在免疫复合物疾病模型中嗜中性粒细胞对毒性氧副产物的生成
J Clin Invest. 1976 Apr;57(4):836-41. doi: 10.1172/JCI108359.
2
H2O2 release from human granulocytes during phagocytosis. Relationship to superoxide anion formation and cellular catabolism of H2O2: studies with normal and cytochalasin B-treated cells.吞噬作用期间人粒细胞释放过氧化氢。与超氧阴离子形成及过氧化氢细胞分解代谢的关系：对正常细胞和经细胞松弛素B处理的细胞的研究
J Clin Invest. 1977 Dec;60(6):1266-79. doi: 10.1172/JCI108886.
3
Superoxide production from human polymorphonuclear leucocytes stimulated with immunoglobulins of different classes and fragments of IgG bound to polystyrene dishes.用不同类别的免疫球蛋白以及与聚苯乙烯培养皿结合的IgG片段刺激人多形核白细胞产生超氧化物。
Immunology. 1978 Oct;35(4):613-8.
4
Stimulation of a human polymorphonuclear leukocyte oxidative response by the C1q subunit of the first complement component.补体第一成分的C1q亚单位对人多形核白细胞氧化反应的刺激作用。
J Immunol. 1982 Jun;128(6):2547-52.
5
Role of toxic oxygen products from phagocytic cells in tissue injury.
Adv Shock Res. 1983;10:27-34.
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Tumour necrosis factor beta (lymphotoxin) inhibits locomotion and stimulates the respiratory burst and degranulation of neutrophils.肿瘤坏死因子β（淋巴毒素）可抑制中性粒细胞的运动，并刺激其呼吸爆发和脱颗粒。
Immunology. 1988 Mar;63(3):507-12.
7
The respiratory burst response to Histoplasma capsulatum by human neutrophils. Evidence for intracellular trapping of superoxide anion.人中性粒细胞对荚膜组织胞浆菌的呼吸爆发反应。超氧阴离子细胞内捕获的证据。
J Immunol. 1990 Jun 15;144(12):4765-72.
8
Generation of superoxide anion and chemiluminescence by human monocytes during phagocytosis and on contact with surface-bound immunoglobulin G.人单核细胞在吞噬过程中以及与表面结合的免疫球蛋白G接触时超氧阴离子的产生和化学发光
J Exp Med. 1976 Jun 1;143(6):1551-6. doi: 10.1084/jem.143.6.1551.
9
The phagocytic system in host defense.宿主防御中的吞噬系统。
Scand J Infect Dis Suppl. 1980;Suppl 24:30-2.
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Cefdinir (CI-983), a new oral amino-2-thiazolyl cephalosporin, inhibits human neutrophil myeloperoxidase in the extracellular medium but not the phagolysosome.头孢地尼（CI-983），一种新型口服氨基-2-噻唑基头孢菌素，可在细胞外介质中抑制人中性粒细胞髓过氧化物酶，但对吞噬溶酶体无抑制作用。
J Immunol. 1994 Mar 1;152(5):2447-55.

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Yacon () Flour Reduces Inflammation and Had No Effects on Oxidative Stress and Endotoxemia in Wistar Rats with Induced Colorectal Carcinogenesis.雪莲（）粉可减轻炎症，但对诱导结直肠癌发生的 Wistar 大鼠的氧化应激和内毒素血症没有影响。
Nutrients. 2023 Jul 24;15(14):3281. doi: 10.3390/nu15143281.
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Effects of Reactive Oxygen Species on in vitro Filtration of Water and Albumin across Glomerular Basement Membrane.活性氧对水和白蛋白跨肾小球基底膜体外滤过的影响。
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Electromagnetic wave emitting products and "Kikoh" potentiate human leukocyte functions.发射电磁波的产品和“基可”增强人体白细胞功能。
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Lipoperoxides as an index of free radical activity in bone marrow transplant recipients. Preliminary observations.脂质过氧化物作为骨髓移植受者自由基活性指标的初步观察
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Inhibition of neutrophil migration by aggregated immunoglobulin attached to micropore membranes.附着于微孔膜的聚集免疫球蛋白对中性粒细胞迁移的抑制作用。
Immunology. 1980 Apr;39(4):529-34.
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Simple procedure for measuring neutrophil chemiluminescence.测量中性粒细胞化学发光的简单方法。
J Clin Microbiol. 1981 Feb;13(2):390-2. doi: 10.1128/jcm.13.2.390-392.1981.
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Increased hydroxyl radical generation by normal polymorphonuclear leukocytes incubated in sera from patients with leukocytoclastic vasculitis.在白细胞破碎性血管炎患者血清中孵育的正常多形核白细胞产生的羟自由基增加。
Arch Dermatol Res. 1982;274(1-2):65-71. doi: 10.1007/BF00510359.
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Auto-oxidative damage in Behçet's disease--endothelial cell damage following the elevated oxygen radicals generated by stimulated neutrophils.白塞病中的自氧化损伤——受刺激的中性粒细胞产生的氧自由基升高后导致的内皮细胞损伤。
Clin Exp Immunol. 1982 Jul;49(1):247-55.
10
Leucocyte function in ulcerative colitis. Quantitative leucocyte mobilisation to skin windows and in vitro function of blood leucocytes.溃疡性结肠炎中的白细胞功能。白细胞向皮肤窗的定量动员及血液白细胞的体外功能。
Gut. 1982 Sep;23(9):758-65. doi: 10.1136/gut.23.9.758.

本文引用的文献

1
Similarities in the mechanisms determining the Arthus and Shwartzman phenomena.决定阿瑟斯现象和施瓦茨曼现象的机制中的相似性。
J Exp Med. 1951 Oct;94(4):347-58. doi: 10.1084/jem.94.4.347.
2
The microestimation of succinate and the extinction coefficient of cytochrome c.琥珀酸的微量测定及细胞色素c的消光系数
Biochim Biophys Acta. 1959 Jul;34:255-6. doi: 10.1016/0006-3002(59)90259-8.
3
A sensitive method for the estimation of hydrogen peroxide in biological materials.一种用于估算生物材料中过氧化氢的灵敏方法。
Nature. 1955 May 14;175(4463):859-60. doi: 10.1038/175859a0.
4
A ROLE OF POLYMORPHONUCLEAR LEUKOCYTES AND COMPLEMENT IN NEPHROTOXIC NEPHRITIS.多形核白细胞和补体在肾毒性肾炎中的作用
J Exp Med. 1965 Jul 1;122(1):99-116. doi: 10.1084/jem.122.1.99.
5
PATHOGENIC FACTORS IN VASULAR LESIONS OF EXPERIMENTAL SERUM SICKNESS.实验性血清病血管病变中的致病因素
J Exp Med. 1965 Jul 1;122(1):83-98. doi: 10.1084/jem.122.1.83.
6
Metalloenzymes and myocardial infarction. II. Malic and lactic dehydrogenase activities and zinc concentrations in serum.金属酶与心肌梗死。II. 血清中苹果酸脱氢酶和乳酸脱氢酶活性及锌浓度
N Engl J Med. 1956 Sep 6;255(10):449-6. doi: 10.1056/NEJM195609062551001.
7
The mechanism of Arthus reactions. I. The role of polymorphonuclear leucocytes and other factors in reversed passive Arthus reactions in rabbits.阿瑟斯反应的机制。一、多形核白细胞及其他因素在兔反向被动阿瑟斯反应中的作用。
Br J Exp Pathol. 1955 Jun;36(3):268-82.
8
Stimulation of human neutrophil leukocyte aerobic glucose metabolism by purified chemotactic factors.纯化趋化因子对人中性粒细胞有氧葡萄糖代谢的刺激作用。
J Clin Invest. 1974 Feb;53(2):591-9. doi: 10.1172/JCI107594.
9
Metabolic and morphological observations on the effect of surface-active agents of leukocytes.关于表面活性剂对白细胞作用的代谢和形态学观察。
J Cell Biol. 1967 Mar;32(3):629-47. doi: 10.1083/jcb.32.3.629.
10
Biopolymer membrane: a model system for the study of the neutrophilic leukocyte response to immune complexes.生物聚合物膜：用于研究嗜中性白细胞对免疫复合物反应的模型系统。
J Immunol. 1971 Aug;107(2):344-52.

在免疫复合物疾病模型中嗜中性粒细胞对毒性氧副产物的生成

Elaboration of toxic oxygen by-products by neutrophils in a model of immune complex disease.

作者信息

Johnston R B, Lehmeyer J E

出版信息

J Clin Invest. 1976 Apr;57(4):836-41. doi: 10.1172/JCI108359.

DOI:10.1172/JCI108359
PMID:181401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC436726/
Abstract

Contact between human neutrophils and aggregated immunoglobulin G bound to micropore filters has been studied as a model of the pathogenesis of tissue damage in immune complex disease. Contact with this surface, as well as with plain filters and polystyrene petri dishes, induced neutrophils to elaborate superoxide anion and hydrogen peroxide and to generate chemiluminescence, which has been attributed to singlet oxygen. Pretreatment of the cells with cytochalasin B decreased these activities but increased release of lysosomal beta-glucuronidase, suggesting that degranulation and the burst of oxygen metabolism that characterizes phagocytes are independently regulated functions. Toxic oxygen metabolites released from neutrophils are highly reactive and could mediate tissue injury at sites of inflammation.

摘要

作为免疫复合物疾病中组织损伤发病机制的模型，人们研究了人类中性粒细胞与结合在微孔滤膜上的聚集免疫球蛋白G之间的相互作用。与该表面以及普通滤膜和聚苯乙烯培养皿接触，会诱导中性粒细胞产生超氧阴离子和过氧化氢，并产生化学发光，这被归因于单线态氧。用细胞松弛素B对细胞进行预处理会降低这些活性，但会增加溶酶体β-葡萄糖醛酸酶的释放，这表明吞噬细胞特有的脱颗粒和氧代谢爆发是独立调节的功能。从中性粒细胞释放的毒性氧代谢产物具有高反应性，可能在炎症部位介导组织损伤。