Van Wimersma Greidanus T B, Maigret C
Department of Pharmacology, Rudolf Magnus Institute, University of Utrecht, The Netherlands.
Eur J Pharmacol. 1991 Dec 10;209(1-2):57-61. doi: 10.1016/0014-2999(91)90010-n.
Neuromedin B and neuromedin C were tested for their grooming/scratching-inducing effects and the composition of neuromedin-induced grooming was established by calculating the relative contribution of various grooming elements to the total grooming scores. Excessive grooming induced by neuromedins is characterized by a predominant display of scratching. Since neuromedin C is much more potent than neuromedin B to induce excessive grooming/scratching behavior, it is concluded that the carboxyl-terminal heptapeptide of neuromedin C is important for this effect. Furthermore, it is concluded that dopamine D1 receptors and opiate receptors are involved in this effect since the dopamine D1 receptor antagonist, SCH 23390, as well as the opiate receptor antagonist, naloxone, suppresses or attenuates neuromedin C-induced excessive grooming/scratching behavior.
对神经介素B和神经介素C的理毛/抓挠诱导作用进行了测试，并通过计算各种理毛元素对总理毛分数的相对贡献来确定神经介素诱导理毛的组成。神经介素诱导的过度理毛的特征是抓挠行为占主导。由于神经介素C比神经介素B诱导过度理毛/抓挠行为的能力强得多，因此得出结论，神经介素C的羧基末端七肽对这种作用很重要。此外，得出结论，多巴胺D1受体和阿片受体参与了这种作用，因为多巴胺D1受体拮抗剂SCH 23390以及阿片受体拮抗剂纳洛酮可抑制或减弱神经介素C诱导的过度理毛/抓挠行为。
