Dutta A S, Chaudhuri A K
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Indian J Exp Biol. 1991 Oct;29(10):937-42.
Neuropharmacological studies have been conducted on the venom of V. russelli on experimental animals. The venom was found to produce alteration in general behaviour pattern, reduction in spontaneous motility, hypothermia, potentiation of pentobarbitone hypnosis, analgesia, reduction in exploratory behaviour pattern, muscle relaxant action, and suppression of aggressive behaviour. The venom caused a significant increase in brain GABA content in mice. The observations are suggestive of a potent CNS-depressant action of V. russelli venom.
已对印度锯鳞蝰毒液在实验动物身上进行了神经药理学研究。发现该毒液会使一般行为模式发生改变、自发运动减少、体温过低、戊巴比妥催眠作用增强、产生镇痛效果、探索行为模式减少、具有肌肉松弛作用以及抑制攻击行为。该毒液使小鼠大脑中的γ-氨基丁酸（GABA）含量显著增加。这些观察结果表明印度锯鳞蝰毒液具有强大的中枢神经系统抑制作用。
