DeSANTO D A, McBIRNIE J E
Calif Med. 1949 Oct;71(4):274-9.
One hundred twenty-four cases of external endometriosis and 95 cases of adenomyosis were analyzed. The two are clinically different diseases which have one feature in common-a reactive fibrosis to aberrant endometrial tissue. They are coexistent in about the same frequency as would result from a noncausal relationship. The origin of external endometriosis from the epithelial "inclusion" cyst is considered proven histologically. This is the source of origin of most external endometriosis, although occasional involvement from regurgitated endometrium probably occurs. Both the endometrial and the serous cysts have a common parentage in this anlage. CERTAIN HISTOLOGICAL FEATURES THAT ARE CONSIDERED PATHOGNOMONIC OF ENDOMETRIOSIS ARE: (1) the minimal lesion, (2) the characteristic cuboidal lined cyst, (3) the siderophagic cyst without lining, and (4) the siderophagic nest. Recognition of the siderophagic nest will permit identification of extinct endometriosis and thus aid in studies to determine the spontaneous or therapeutically induced regression of the disease. The coexistence of endometriosis with other pelvic pathological changes, notably carcinoma, indicates the need for further studies to search the possibility of relationship. The ability of ectopic deposits of endometrium to become malignant on rare occasions would appear to be proven, but it is a rare occurrence and there is no justification for regarding endometriosis as a premalignant disease.
对124例外在性子宫内膜异位症和95例子宫腺肌病进行了分析。这两种疾病在临床上是不同的，但有一个共同特征——对异常子宫内膜组织产生反应性纤维化。它们同时存在的频率与非因果关系所导致的频率大致相同。外在性子宫内膜异位症起源于上皮性“包涵”囊肿，这在组织学上已被证实。这是大多数外在性子宫内膜异位症的起源，尽管偶尔也可能是逆流的子宫内膜所致。在这个原基中，子宫内膜囊肿和浆液性囊肿有共同的起源。被认为是子宫内膜异位症特征性的某些组织学特征包括：（1）最小病变；（2）特征性立方上皮衬里囊肿；（3）无衬里的含铁血黄素吞噬细胞囊肿；（4）含铁血黄素吞噬细胞巢。识别含铁血黄素吞噬细胞巢将有助于识别已消退的子宫内膜异位症，从而有助于研究确定该疾病的自发或治疗性消退情况。子宫内膜异位症与其他盆腔病理变化，尤其是癌症同时存在，表明需要进一步研究以探寻两者之间存在关联的可能性。子宫内膜异位灶在极少数情况下发生恶变的能力似乎已得到证实，但这是罕见情况，没有理由将子宫内膜异位症视为癌前疾病。
