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1
Observations on the release of serum fibrinolysin by specific antigen, peptone, and certain polysaccharides.关于特定抗原、蛋白胨和某些多糖对血清纤维蛋白溶酶释放的观察
J Exp Med. 1949 Jul;90(1):39-51. doi: 10.1084/jem.90.1.39.
2
Activation of profibrinolysin by antigen-antibody reaction and by anaphylactoid agents; its relation to complement.通过抗原 - 抗体反应和类过敏剂激活纤维蛋白溶酶原；其与补体的关系。
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3
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Studies on the fibrinolysin-antifibrinolysin system in serum. I. Action of the anterior pituitary, adrenal cortex, and spleen.血清中纤维蛋白溶酶-抗纤维蛋白溶酶系统的研究。I. 垂体前叶、肾上腺皮质和脾脏的作用。
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9
Tissue reactions to anaphylactic and anaphylactoid stimuli; proteolysis and release of histamine and heparin.组织对过敏和类过敏刺激的反应；蛋白水解以及组胺和肝素的释放。
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10
Selective necrosis of cardiac and skeletal muscle induced experimentally by means of proteolytic enzyme solutions given intravenously.通过静脉注射蛋白水解酶溶液实验性诱导的心肌和骨骼肌选择性坏死。
J Exp Med. 1954 Apr 1;99(4):387-404. doi: 10.1084/jem.99.4.387.

本文引用的文献

1
BIOCHEMICAL STUDIES ON THE FIBRINOLYTIC ACTIVITY OF HEMOLYTIC STREPTOCOCCI : I. ISOLATION AND CHARACTERIZATION OF FIBRINOLYSIN.溶血性链球菌纤溶活性的生化研究：I. 纤溶酶的分离与鉴定。
J Exp Med. 1934 Jul 31;60(2):239-54. doi: 10.1084/jem.60.2.239.
2
Studies on a proteolytic enzyme in human plasma; some factors controlling the rate of fibrinolysis.人体血浆中一种蛋白水解酶的研究；控制纤维蛋白溶解速率的一些因素。
J Exp Med. 1948 Oct 1;88(4):401-16. doi: 10.1084/jem.88.4.401.
3
The inhibition of histamine release by a pituitary-adrenal mechanism.垂体 - 肾上腺机制对组胺释放的抑制作用。
J Physiol. 1944 Dec 15;103(3):333-43. doi: 10.1113/jphysiol.1944.sp004081.

关于特定抗原、蛋白胨和某些多糖对血清纤维蛋白溶酶释放的观察

Observations on the release of serum fibrinolysin by specific antigen, peptone, and certain polysaccharides.

作者信息

UNGAR G, MIST S H

出版信息

J Exp Med. 1949 Jul;90(1):39-51. doi: 10.1084/jem.90.1.39.

DOI:10.1084/jem.90.1.39
PMID:18152338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2135937/
Abstract

FORMATION OF FIBRINOLYSIN FROM ITS INACTIVE PRECURSOR IN SERUM WAS OBSERVED UNDER THE FOLLOWING CONDITIONS

(a) by adding the specific antigen to serum from sensitized guinea pigs; (b) by mixing normal guinea pig serum with peptone, agar, hyaluronic acid, chondroitinsulfuric acid, glycogen, pneumococcal polysaccharides, and heparin. Activation of profibrinolysin by these agents differs from chloroform or streptokinase activation in that it requires the presence of some serum constituent non-precipitable with the euglobulin fraction and destroyed by heating at 56 degrees C. The bearing of these observations on the mechanism of anaphylactic and anaphylactoid reactions is discussed. The findings reported support the concept that proteolysis is part of the process determining the release of histamine and other toxic products. It is suggested that the presence of fibrinokinase may be responsible for the toxicity of serum induced in vitro by a number of agents.

摘要

在下列条件下观察到血清中纤维蛋白溶酶由其无活性前体形成

(a) 向致敏豚鼠的血清中加入特异性抗原；(b) 将正常豚鼠血清与蛋白胨、琼脂、透明质酸、硫酸软骨素、糖原、肺炎球菌多糖和肝素混合。这些试剂对纤维蛋白溶酶原的激活与氯仿或链激酶激活不同，因为它需要存在一些不能被优球蛋白部分沉淀且在56℃加热会被破坏的血清成分。讨论了这些观察结果对过敏反应和类过敏反应机制的意义。所报道的研究结果支持蛋白水解是决定组胺和其他毒性产物释放过程的一部分这一概念。有人提出，纤维蛋白激酶的存在可能是多种试剂在体外诱导血清毒性的原因。