UNGAR G, DAMGAARD E
J Exp Med. 1951 Jan;93(1):89-97. doi: 10.1084/jem.93.1.89.
Injection of ACTH or cortisone has no effect on the amount of fibrinolysin resulting from the activation of profibrinolysin by peptone. Antifibrinolytic activity of serum is significantly increased by ACTH or cortisone but not by desoxycorticosterone or corticosterone. No increase in anti-fibrinolytic power of serum is produced, however, by the injection of ACTH or cortisone in splenectomized guinea pigs. Splenin A has the same action on fibrinolysin inactivation as ACTH or cortisone. Splenin B has the opposite effect. This action on the antifibrinolytic power of serum appears to be due to an acceleration of the rate of combination between the enzyme and its inhibitor and not to an actual increase in antifibrinolysin. The possible significance of these observations is discussed.
注射促肾上腺皮质激素（ACTH）或可的松对由蛋白胨激活纤维蛋白溶酶原所产生的纤维蛋白溶酶量没有影响。血清的抗纤维蛋白溶解活性会因ACTH或可的松而显著增加，但脱氧皮质酮或皮质酮则不会。然而，在切除脾脏的豚鼠中注射ACTH或可的松并不会使血清的抗纤维蛋白溶解能力增加。脾素A对纤维蛋白溶酶失活的作用与ACTH或可的松相同。脾素B则有相反的效果。血清抗纤维蛋白溶解能力的这种作用似乎是由于酶与其抑制剂之间结合速率的加快，而不是抗纤维蛋白溶酶的实际增加。讨论了这些观察结果可能的意义。
