多发性硬化症中红细胞沉降率的亚油酸依赖性减缓
Linoleic-acid-dependent slowing of erythrocyte sedimentation in multiple sclerosis.
作者信息
Mayer M
机构信息
Department of Neurology, Medical Faculty of the Palacký University, Olomouc, Czechoslovakia.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 1991 Dec;44(4):257-8. doi: 10.1016/0952-3278(91)90027-3.
The influence of linoleic acid upon the sedimentation of washed erythrocytes from multiple sclerosis patients and controls was investigated in the present study. Linoleic acid, especially in the concentration of 250 microM and 500 microM, caused slowing of erythrocyte sedimentation and this effect was significantly greater in multiple sclerosis than in controls. These findings with all probability reflect an unsaturated fatty acid-dependent membrane alteration in multiple sclerosis and are analogues to results obtained earlier by several authors by using cytopherometric measurements.
本研究调查了亚油酸对多发性硬化症患者和对照组洗涤红细胞沉降的影响。亚油酸，尤其是浓度为250微摩尔和500微摩尔时，会导致红细胞沉降减慢，且这种效应在多发性硬化症患者中比在对照组中显著更大。这些发现很可能反映了多发性硬化症中不饱和脂肪酸依赖性的膜改变，并且与几位作者早期通过细胞光度测量获得的结果相似。
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