红细胞不饱和脂肪酸试验的进一步观察。对多发性硬化症遗传学的一项贡献。

Further observations with the erythrocyte-unsaturated fatty acid test. A contribution to the genetics of multiple sclerosis.

作者信息

Joyce G, Field E J

出版信息

Eur Neurol. 1980;19(4):266-72. doi: 10.1159/000115159.

Abstract

The absolute electrophoretic mobility of RBC of near relatives of multiple sclerosis (MS) patients has been studied in the presence of 0.08 mg/ml linoleic (LA) or arachidonic acid (AA). 42.9% of near relatives show anomalous results (slow with LA, fast with AA), chiefly females, and mothers always. The effect of LA is greater in clinical MS than in 'anomalous' relatives. Silent MS is recorded in 1 in 45 of near relatives, so that the 'disease' is much more common than the usual 5--20 times described in clinical surveys but corresponds with clinical occurrence in the Orkney Islands. Children (below the age of 14 years) with MS have been picked out with the same frequency as in adults. The sibship position of anomalous relatives has been studied where possible.

摘要

在存在0.08mg/ml亚油酸（LA）或花生四烯酸（AA）的情况下，对多发性硬化症（MS）患者近亲的红细胞绝对电泳迁移率进行了研究。42.9%的近亲显示出异常结果（在LA存在下迁移缓慢，在AA存在下迁移快速），主要为女性，且总是母亲。LA对临床MS患者的影响比对“异常”亲属的影响更大。在45名近亲中有1人被记录为无症状MS，因此这种“疾病”比临床调查中通常描述的常见5 - 20倍更为普遍，但与奥克尼群岛的临床发病率相符。患有MS的儿童（14岁以下）被挑选出的频率与成年人相同。在可能的情况下，对异常亲属的同胞关系位置进行了研究。