红细胞电泳迁移率试验用于多发性硬化症的早期诊断。

Red cell electrophoretic mobility test for early diagnosis of multiple sclerosis.

作者信息

Tamblyn C H, Swank R L, Seaman G V, Zukoski C F

出版信息

Neurol Res. 1980;2(1):69-83. doi: 10.1080/01616412.1980.11739572.

DOI:10.1080/01616412.1980.11739572

Abstract

We have confirmed the red cell electrophoretic mobility-unsaturated fatty acid test for multiple sclerosis, which involves measuring the change in electrophoretic mobility of erythrocytes in Medium 199 upon the addition of linoleic acid. Using defibrinated blood samples, the average decrease in the mobility of red cells upon the addition of linoleic acid of 57 multiple sclerosis patients was 6.7 +/- 2.1% and that of 23 normal control subjects was .09 +/- 1.2% (p less than 0.001). In addition, blood anticoagulated with trisodium citrate was found to give similar test results, and such preparations were found to be simpler and quicker to use.

摘要

我们已经证实了用于多发性硬化症的红细胞电泳迁移率-不饱和脂肪酸试验，该试验包括测量在199培养基中加入亚油酸后红细胞电泳迁移率的变化。使用去纤维蛋白血样，57例多发性硬化症患者加入亚油酸后红细胞迁移率的平均下降为6.7±2.1%，23例正常对照者为0.09±1.2%（p<0.001）。此外，发现用柠檬酸钠抗凝的血液能给出相似的试验结果，并且发现这种制剂使用起来更简单、更快捷。