Samuelsson S, Gustavsen S, Rønne T
Department of Epidemiology, Statens Seruminstitut, Copenhagen, Denmark.
Scand J Infect Dis. 1991;23(6):723-30. doi: 10.3109/00365549109024300.
Based on epidemiological data of notified cases of meningococcal disease (MD) in Denmark during the period 1980-88 the recommendations for prophylaxis are evaluated. In 1986 the incidence of MD increased about 60% to 5.5 per 100,000 population. The clinical diagnosis of MD was verified by culture of Neisseria meningitidis in 79% of notified cases. About 40% of all patients were less than 4 years of age. The mortality in 1988 was found to be 10%. Serogroup B disease accounted for about 80% of the cases. Two co-primary and 28 secondary cases were registered. Two major outbreaks of serogroup C disease occurred in 1984 and 1986, respectively. In small clusters of 2-3 cases within socially well-defined groups the recommendations for prophylaxis are sufficient. But for the new pattern of clusters spread over months to years in certain geographical areas or open social groups, especially among teenagers, the existing recommendations are insufficient. The occurrence of localized clusters of serogroup B disease emphasises the need for a vaccine against serogroup B disease.
根据丹麦1980 - 1988年期间报告的脑膜炎球菌病（MD）病例的流行病学数据，对预防建议进行了评估。1986年，MD的发病率增加了约60%，达到每10万人中5.5例。在79%的报告病例中，通过脑膜炎奈瑟菌培养证实了MD的临床诊断。所有患者中约40%年龄小于4岁。1988年的死亡率为10%。B群疾病约占病例的80%。登记了2例共同原发病例和28例继发病例。C群疾病分别在1984年和1986年发生了两次主要暴发。在社会定义明确的群体中2 - 3例的小聚集性病例中，预防建议是足够的。但对于在某些地理区域或开放社会群体中持续数月至数年的新聚集模式，特别是在青少年中，现有建议是不够的。B群疾病局部聚集性病例的出现强调了需要一种针对B群疾病的疫苗。
