Almog R, Block C, Gdalevich M, Lev B, Wiener M, Ashkenazi S
Medical Corps, Israel Defence Force, Petah Tiqva.
Infection. 1994 Mar-Apr;22(2):69-71. doi: 10.1007/BF01739006.
Outbreaks of meningococcal disease were observed for the first time in the Israel Defence Force (I.D.F.) in 1992 and 1993, while in previous years, cases appeared in sporadic fashion. Two episodes in the winter of 1992 involving three and two individuals, respectively, were caused by Neisseria meningitidis group C, which was nontypable and nonsubtypable (C:NT:-). Three cases in one event in early 1993 were due to group C:NT:P1.2, the two secondary cases being caused by strains completely resistant to rifampicin. While these outbreaks were small, they should be seen against a background of the emergence of relatively virulent clones of serogroup C which have caused significant outbreaks in several countries. This and the drug resistance problem will require medical decision-makers to review strategies for the prevention of meningococcal disease, taking into account alternative agents for chemoprophylaxis as well as a possible role for vaccination.
1992年和1993年，以色列国防军首次观察到脑膜炎球菌病的爆发，而在之前的年份里，病例呈散发性出现。1992年冬季的两起疫情分别涉及三人及两人，由C群脑膜炎奈瑟菌引起，该菌株无法分型且无法进一步细分（C:NT:-）。1993年初一起事件中的三例病例是由C:NT:P1.2群引起的，两例继发病例是由对利福平完全耐药的菌株引起的。虽然这些疫情规模较小，但应结合C群相对毒力较强的克隆株出现的背景来看待，这些克隆株已在多个国家引发了重大疫情。这一情况以及耐药性问题将要求医学决策者重新审视预防脑膜炎球菌病的策略，同时考虑化学预防的替代药物以及疫苗接种可能发挥的作用。
