表皮生长因子受体抑制剂（EGFRI）所致皮肤毒性的临床表现及病理生理学

Clinical presentation and pathophysiology of EGFRI dermatologic toxicities.

作者信息

Mitchell Edith P, Perez-Soler Roman, Van Cutsem Eric, Lacouture Mario E

机构信息

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

出版信息

Oncology (Williston Park). 2007 Oct;21(11 Suppl 5):4-9.

PMID:18154212

Abstract

This review summarizes the pathophysiology and clinical presentation of the cutaneous toxicities associated with EGFR inhibition. Such effects include papulopustular reactions, xerosis, pruritus, fissures, nail changes, hair changes, telangiectasias, hyperpigmentation, and mucositis. Most management strategies for these toxicities have been based on anecdotal experience; clinical trials are needed to provide uniform characterization to allow for evidence-based treatment strategies.

摘要

本综述总结了与表皮生长因子受体（EGFR）抑制相关的皮肤毒性的病理生理学和临床表现。这些效应包括丘疹脓疱反应、皮肤干燥、瘙痒、皮肤皲裂、指甲改变、毛发改变、毛细血管扩张、色素沉着和粘膜炎。针对这些毒性的大多数管理策略都基于经验；需要进行临床试验以提供统一的特征描述，从而制定基于证据的治疗策略。