Poirel L, Naas T, Nordmann P
Service de Bactériologie-Virologie, Hôpital de Bicêtre, South-Paris Medical School, University Paris XI, Le Kremlin-Bicêtre, France.
Clin Microbiol Infect. 2008 Jan;14 Suppl 1:75-81. doi: 10.1111/j.1469-0691.2007.01865.x.
Genes encoding extended-spectrum beta-lactamases (ESBLs) have been reported in a variety of Gram-negative species, mostly in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii. They are mostly either TEM or SHV derivatives, CTX-M-like enzymes--now emerging worldwide--or, less frequently, VEB, GES, and PER ESBLs. The mechanisms responsible for their acquisition are very diverse, and mostly are related to insertion sequences (ISs), transposons, class 1 integrons, and also sul1-type integrons containing the ISCR1 element. This diversity of genetic vehicles at the origin of these mobilisation/acquisition processes enhances the spread of ESBLs.
编码超广谱β-内酰胺酶（ESBLs）的基因已在多种革兰氏阴性菌中被报道，主要存在于肠杆菌科、铜绿假单胞菌和鲍曼不动杆菌中。它们大多是TEM或SHV的衍生物、CTX-M样酶（目前在全球范围内出现），或者较少见的VEB、GES和PER ESBLs。其获得的机制非常多样，主要与插入序列（ISs）、转座子、1类整合子以及含有ISCR1元件的sul1型整合子有关。这些介导/获得过程起源的遗传载体的多样性促进了ESBLs的传播。
