Rodríguez-Baño J, Navarro M D
Sección de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena, Sevilla, Spain.
Clin Microbiol Infect. 2008 Jan;14 Suppl 1:104-10. doi: 10.1111/j.1469-0691.2007.01866.x.
Extended-spectrum beta-lactamase (ESBL)-producing organisms are emerging as a cause of infection in outpatients in many areas of the world. Most of these involve urinary tract infections caused by Escherichia coli harbouring CTX-M types of ESBLs. Risk-factors for such infections include older age and previous use of quinolones and cephalosporins. Oral alternatives for such infections are limited. These organisms may also cause some community-acquired life-threatening infections, such as bacteraemic urinary tract or intra-abdominal infections. Patients with these infections are at increased probability of receiving inappropriate empirical treatment. More studies addressing the risk-factors and therapeutic options for these infections are needed.
产超广谱β-内酰胺酶（ESBL）的微生物正在成为世界许多地区门诊患者感染的一个原因。其中大多数涉及由携带CTX-M型ESBL的大肠埃希菌引起的尿路感染。此类感染的风险因素包括年龄较大以及既往使用喹诺酮类和头孢菌素类药物。针对此类感染的口服替代药物有限。这些微生物还可能引起一些社区获得性危及生命的感染，如菌血症性尿路感染或腹腔内感染。患有这些感染的患者接受不恰当经验性治疗的可能性增加。需要更多针对这些感染的风险因素和治疗选择的研究。
