Oliveira L H S, Rosa M L G, Cavalcanti S M B
Department of Microbiology and Parasitology, Fluminense Federal University, Niterói, RJ, Brazil.
Clin Microbiol Infect. 2008 Jan;14(1):60-5. doi: 10.1111/j.1469-0691.2007.01887.x.
The relationship between severe-grade cervical lesions and clusters of human papillomavirus (HPV) genotypes in a taxonomic classification was surveyed in 232 women with previous abnormal cytology. HPV co-infections were clustered according to phylogenetic criteria. Multiple infections were detected in 22.0% of the entire sample. Clade A10 (represented by HPV-6 and HPV-11) appeared more frequently in multiple infections than clade A9, which was represented by five of the most common high-risk types, including HPV-16. Although HPV-16 was the most frequent genotype, it was not more prevalent in multiple infections. Abortion and two or more sexual partners were risk-factors associated with HPV co-infections. Severe cervical dysplasia was associated with co-infections with oncogenic types from different clades, with the association being significant for the high-risk clades A7 and A9.
在232名既往细胞学异常的女性中，调查了严重程度的宫颈病变与分类学分类中的人乳头瘤病毒（HPV）基因型簇之间的关系。HPV合并感染根据系统发育标准进行聚类。在整个样本的22.0%中检测到多重感染。A10进化枝（以HPV-6和HPV-11为代表）在多重感染中比A9进化枝出现得更频繁，A9进化枝由包括HPV-16在内的五种最常见高危类型代表。虽然HPV-16是最常见的基因型，但在多重感染中它并不更普遍。流产和两个或更多性伴侣是与HPV合并感染相关的危险因素。严重宫颈发育异常与来自不同进化枝的致癌类型的合并感染有关，对于高危进化枝A7和A9，这种关联具有显著性。
