Kulmala Satu-Maria A, Shabalova Irena P, Petrovitchev Nikolay, Syrjänen Kari J, Gyllensten Ulf B, Syrjänen Stina M
Department of Oral Pathology, Institute of Dentistry, MediCity Research Laboratory, University of Turku, Turku, Finland.
J Med Virol. 2007 Jun;79(6):771-81. doi: 10.1002/jmv.20839.
Type distribution of HPV has been studied in different geographic regions, but the data are scanty from the new independent states of the former Soviet Union. Here the HPV prevalence and distribution of the most frequent high-risk HPV types among 3,187 women at different risk for HPV and cervical intraepithelial neoplasia in Russia, Belarus, and Latvia is reported. HPV detection, type distribution and viral load analysis in DNA samples from cervical scrapes were done with real-time PCR-based assay detecting HPV types 16, 18, 31, 33, 35, 39, 45, 52, and 58. The overall HPV prevalence was 31.2%, HPV16 was the most prevalent type followed by HPV31 and HPV33 group. The overall HPV prevalences in Russia, Belarus and Latvia were 33.4%, 27.5%, and 26.2%. The type distributions were similar in these countries, except for Latvia where HPV39 was the third prevalent genotype. HPV prevalence was highest (40.8%) among women from sexually transmitted disease clinic, followed by 30.9% among gynecological outpatients and 27.2% in screening patients. HPV detection increased with cytological abnormality (P = 0.0001) and lesion grade in the biopsy (P = 0.0001), from 27% to 72% in normal samples to cancer, and from 64% to 77% in cervical intraepithelial neoplasia 1 to cancer. The normalized viral loads varied greatly between and among different HPV-types. The mean log HPV33 group copies/cell increased from negative for intraepithelial lesions to cancer (P = 0.049). Distribution of the most common high-risk HPV-types seems to be similar in these countries as reported in other major geographical regions.
人们已对不同地理区域的人乳头瘤病毒（HPV）类型分布展开研究，但前苏联新独立国家的数据却很匮乏。本文报告了俄罗斯、白俄罗斯和拉脱维亚3187名面临不同HPV和宫颈上皮内瘤变风险的女性中HPV的流行情况以及最常见高危HPV类型的分布。采用基于实时聚合酶链反应（PCR）的检测方法，对宫颈刮片DNA样本进行HPV检测、类型分布及病毒载量分析，可检测HPV 16、18、31、33、35、39、45、52和58型。HPV总体流行率为31.2%，HPV16是最常见类型，其次是HPV31和HPV33组。俄罗斯、白俄罗斯和拉脱维亚的HPV总体流行率分别为33.4%、27.5%和26.2%。这些国家的类型分布相似，但在拉脱维亚，HPV39是第三常见的基因型。性传播疾病诊所女性中的HPV流行率最高（40.8%），其次是妇科门诊患者中的30.9%和筛查患者中的27.2%。HPV检测率随细胞学异常（P = 0.0001）和活检病变分级（P = 0.0001）而增加，正常样本至癌症时从27%增至72%，宫颈上皮内瘤变1级至癌症时从64%增至77%。不同HPV类型之间及之内的标准化病毒载量差异很大。HPV33组每细胞平均对数拷贝数从上皮内病变阴性增至癌症（P = 0.049）。这些国家中最常见高危HPV类型的分布似乎与其他主要地理区域报告的情况相似。
