Carlsen Berit Christina, Andersen Klaus Ejner, Menné Torkil, Johansen Jeanne Duus
National Allergy Research Centre, Department of Dermatology, Copenhagen University Hospital Gentofte, 2820 Gentofte, Denmark.
Contact Dermatitis. 2008 Jan;58(1):1-8. doi: 10.1111/j.1600-0536.2007.01232.x.
Patients with multiple contact allergies, also referred to as polysensitized, are more frequent than predicted from prevalence of single sensitivities. The understanding of why some people develop multiple contact allergies, and characterization of patients with multiple contact allergies is limited. This review presents the current knowledge on the topic and discusses the evidence and characteristics of an increased susceptibility factor, possible causes to and genetic markers for the increased susceptibility, composition of the patient group and identification of patients at risk of developing multiple contact allergies. Evidence of allergen clusters among polysensitized individuals is also reviewed. The literature supports the idea that patients with multiple contact allergies constitute a special entity within the field of contact allergy. There is no generally accepted definition of patients with multiple contact allergies. We suggest that contact allergy to 3 or more allergens are defined as multiple contact allergies.
患有多种接触性过敏（也称为多敏化）的患者比根据单一敏感性患病率预测的更为常见。对于为何有些人会出现多种接触性过敏以及对患有多种接触性过敏患者的特征描述，目前了解有限。本综述介绍了该主题的当前知识，并讨论了易感性增加因素的证据和特征、易感性增加的可能原因和遗传标记、患者群体组成以及识别有发生多种接触性过敏风险的患者。还综述了多敏化个体中过敏原簇的证据。文献支持这样一种观点，即患有多种接触性过敏的患者在接触性过敏领域构成一个特殊群体。目前对于患有多种接触性过敏的患者尚无普遍接受的定义。我们建议将对3种或更多过敏原的接触性过敏定义为多种接触性过敏。
