Svedman Cecilia, Ekqvist Susanne, Möller Halvor, Björk Jonas, Gruvberger Birgitta, Holmström Eva, Bruze Magnus
Department of Occupational and Environmental Dermatology, University Hospital MAS, Malmö, Lund University, Lund, Sweden.
Contact Dermatitis. 2007 Jun;56(6):338-43. doi: 10.1111/j.1600-0536.2007.01119.x.
Contact allergy to stent material has been proposed to be a risk factor for restenosis, after percutaneous transluminal coronary angioplasty (PTCA) and stenting. Information on the general frequency of contact allergy in the elderly population is scarce and knowledge of possible sensitization routes is important to investigate. The aim of this study was to investigate contact allergy to stent materials and other allergens. Here we report our findings on the frequency of contact allergies apart from those from stent material. In this retrospective study, we patch tested an elderly population, treated with PTCA and stented, with our standard series. A dermatitis population served as controls. We found a high frequency of contact allergy in both groups but a greater 'contact allergy burden', with generally higher frequencies for contact allergens, in the dermatitis patients as expected. Myroxylon pereirae and caine mix were apart from metals exceptions with statistically significant higher frequencies (P < 0.01) for the stented patients. Contact allergy to nonmetal sensitizers is common in an elderly Swedish stent population although, on the whole, substantially less than in an age and sex-matched dermatitis population. The findings indicate the importance of the oral mucosa for sensitization. In a general population that has been treated with a special medication/treatment procedure, contact allergies not suspected (such as to M. pereirae and to the metals) might suddenly peak. This underlines the importance of a careful evaluation of new products and routines with regard to contact allergies in the population.
经皮腔内冠状动脉成形术（PTCA）和支架置入术后，对支架材料的接触性过敏被认为是再狭窄的一个危险因素。关于老年人群中接触性过敏的总体发生率的信息匮乏，而了解可能的致敏途径对于开展研究很重要。本研究的目的是调查对支架材料和其他过敏原的接触性过敏情况。在此，我们报告除支架材料接触性过敏之外的接触性过敏发生率的研究结果。在这项回顾性研究中，我们用标准系列对接受PTCA并置入支架的老年人群进行了斑贴试验。以皮炎患者作为对照。我们发现两组中接触性过敏的发生率都很高，但正如预期的那样，皮炎患者的“接触性过敏负担”更大，接触过敏原的频率总体上更高。除金属外，秘鲁香脂和卡因混合物在置入支架的患者中出现的频率具有统计学显著差异（P < 0.01）。在瑞典老年置入支架人群中，对非金属致敏剂的接触性过敏很常见，不过总体上远低于年龄和性别匹配的皮炎人群。研究结果表明口腔黏膜在致敏方面的重要性。在接受特殊药物/治疗程序的普通人群中，未被怀疑的接触性过敏（如对秘鲁香脂和金属的过敏）可能会突然激增。这凸显了在人群中就接触性过敏对新产品和常规操作进行仔细评估的重要性。
