Pesqué David, Planella-Fontanillas Nidia, Borrego Leopoldo, Sanz-Sánchez Tatiana, Zaragoza-Ninet Violeta, Serra-Baldrich Esther, Miquel-Miquel Francisco Javier, Silvestre-Salvador Juan Francisco, Córdoba-Guijarro Susana, Sánchez-Gilo Araceli, Mercader-García Pedro, Navarro-Triviño Francisco José, Ortiz-de-Frutos Francisco Javier, Tous-Romero Fátima, Rodríguez-Serna Mercedes, Melé-Ninot Gemma, Barrabés-Torrella Cristina, Ruiz-González Inmaculada, Pastor-Nieto María Antonia, Carrascosa-Carrillo José Manuel, Gómez-de-la-Fuente Enrique, Sánchez-Pedreño-Guillén Paloma, Sánchez-Pérez Javier, Pereyra-Rodríguez José Juan, Gatica-Ortega María Elena, González-Pérez Ricardo, Pujol Ramon Maria, Descalzo Miguel Ángel Gallego, García-Doval Ignacio, Giménez-Arnau Ana María
Servicio de Dermatología, Hospital del Mar Research Institute, Barcelona, Spain.
Departament de Medicina, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
Contact Dermatitis. 2025 Feb;92(2):120-130. doi: 10.1111/cod.14702. Epub 2024 Oct 12.
Patch test results may be influenced by age-related factors. However, there is still discordant evidence between age and patch test results.
We aim to evaluate the patch test results reflecting skin sensitisation, their relevance and association with clinical features by age group.
Prospective multicentric study of all patients patch tested with the Spanish baseline series in participating centres. Age groups were pre-defined as children (0- to 11-years), adolescents (12- to 18-years), young adults (19- to 30-years), middle-aged adults (31- to 65-years) and older adults (≥66-years). Occurrence of sensitisation, relevance and clinical features were compared by age group. Factors associated with skin sensitisation were investigated with multivariate logistic regression.
A total of 13 368 patients were patch-tested. Differences in positive patch test results and relevance by age were detected with the highest proportion in middle-aged adults. Age-related trend differences were found for nickel, potassium dichromate, caines, colophony, Myroxylon pereirae resin, 2-hydroxyethyl methacrylate and limonene hydroperoxide. The multivariate logistic analysis (adjusted for sex, atopic dermatitis, body location and occupational dermatitis) showed an association between the age group of 31-65 (OR: 1.41, 95% CI: 1.26-1.58) and above 66-years (OR: 1.15, 95% CI: 1.01-1.32) with a higher proportion of positive results, compared with young adults.
Positive patch test results vary according to age, with the highest occurrence in middle-aged adults. Most haptens did not present age-related differences, reinforcing the use of baseline series regardless of age.
斑贴试验结果可能受年龄相关因素影响。然而，年龄与斑贴试验结果之间仍存在不一致的证据。
我们旨在按年龄组评估反映皮肤致敏的斑贴试验结果、其相关性以及与临床特征的关联。
在参与中心对所有使用西班牙基线系列进行斑贴试验的患者进行前瞻性多中心研究。年龄组预先定义为儿童（0至11岁）、青少年（12至18岁）、青年成年人（19至30岁）、中年成年人（31至65岁）和老年人（≥66岁）。按年龄组比较致敏的发生率、相关性和临床特征。通过多变量逻辑回归研究与皮肤致敏相关的因素。
共有13368名患者接受了斑贴试验。检测到斑贴试验阳性结果和相关性在年龄上存在差异，中年成年人中的比例最高。发现镍、重铬酸钾、卡因类、松香、秘鲁香脂树脂、甲基丙烯酸2-羟乙酯和氢过氧化苎烯存在与年龄相关的趋势差异。多变量逻辑分析（对性别、特应性皮炎、身体部位和职业性皮炎进行校正）显示，与青年成年人相比，31至65岁年龄组（比值比：1.41，95%置信区间：1.26至1.58）和66岁以上年龄组（比值比：1.15，95%置信区间：1.01至1.32）的阳性结果比例更高。
斑贴试验阳性结果因年龄而异，中年成年人中发生率最高。大多数半抗原不存在与年龄相关的差异，这支持无论年龄如何都使用基线系列。
